SCAMP2 - secretory carrier membrane protein 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10066

About SCAMP2

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,843,730-74,873,365 (from NCBI)

This gene has 12 transcripts (splice variants), 272 orthologues and 4 paralogues. Ubiquitous expression in colon (RPKM 41.0), small intestine (RPKM 37.7) and 25 other tissues.

Summary

This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

SCAMP2 Products (2)

mRNA Protein Name
NM_001320778.2 NP_001307707.1 secretory carrier-associated membrane protein 2 isoform 1
NM_005697.5 NP_005688.2 secretory carrier-associated membrane protein 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15840657 GOA
Biological Process GO Annotation Evidence References Source
involved in protein transport IDA
IDA: Inferred from direct assay
15840657 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
15840657 GOA
located in recycling endosome membrane IDA
IDA: Inferred from direct assay
15840657 GOA
located in trans-Golgi network membrane IDA
IDA: Inferred from direct assay
15840657 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCAMP2 Protein Structure

SCAMP

SCAMP: SCAMP family (116 - 294)

  • 0
  • 100
  • 200
  • 300
  • 329 a.a.
Protein Preferred Names Protein Names

secretory carrier-associated membrane protein 2

  • testis secretory sperm-binding protein Li 219p

SCAMP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SCAMP2 O15127 SLC41A1 Homo sapiens Q8IVJ1
Validated Y2H
32296183
Intra
SCAMP2 O15127 FLNA Homo sapiens P21333-2
Validated Y2H
32814053
Intra
SCAMP2 O15127 FLNA Homo sapiens P21333-2
Y2H Pooling
32814053
Intra
SCAMP2 O15127 FLNA Homo sapiens P21333-2
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chromosome 15q24 Deletion Syndrome

  • 15q24 Microdeletion Syndrome

  • Del(15)(Q24)

  • Monosomy 15q24

  • 15q24 Microdeletion

  • 15q24 Deletion

  • Interstitial Deletion Of Chromosome 15q24
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12479 SCAMP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SCAMP2 VGNC VGNC:64896
Macaca mulatta SCAMP2 VGNC VGNC:76974
Bos taurus SCAMP2 VGNC VGNC:34316
Rattus norvegicus SCAMP2 RGD RGD:68348
Mus musculus SCAMP2 MGD MGI:1346518
Canis familiaris SCAMP2 VGNC VGNC:45891
Others SCAMP2 NCBI