RCL1 - RNA terminal phosphate cyclase like 1 Gene

Also Known as RNAC; RPCL1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10171

About RCL1

Cytogenetic location: 9p24.1 Genomic coordinates (GRCh38): 9:4,792,944-4,861,066 (from NCBI)

This gene has 9 transcripts (splice variants), 205 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 21.6), fat (RPKM 15.5) and 25 other tissues.

Summary

Predicted to enable endoribonuclease activity. Predicted to be involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to act upstream of or within endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleoplasm. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

RCL1 Products (4)

mRNA	Protein	Name
NM_001286699.2	NP_001273628.1	RNA 3'-terminal phosphate cyclase-like protein isoform b
NM_001286700.2	NP_001273629.1	RNA 3'-terminal phosphate cyclase-like protein isoform b
NM_001286701.2	NP_001273630.1	RNA 3'-terminal phosphate cyclase-like protein isoform c
NM_005772.5	NP_005763.3	RNA 3'-terminal phosphate cyclase-like protein isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RCL1 Protein Structure

RTC

RTC_insert

0
100
200
300
373 a.a.

Protein Preferred Names	Protein Names
RNA 3'-terminal phosphate cyclase-like protein	RNA cyclase homolog

RCL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RCL1	Q9Y2P8	BMS1	Homo sapiens	Q14692	Anti Tag CoIP	33961781
Intra	RCL1	Q9Y2P8	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	RCL1	Q9Y2P8	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Breast Lipoma	Lipoma Of Breast
Intracranial Arteriosclerosis
Microphthalmia, Syndromic 10	MCOPS10 Moba Microphthalmia And Brain Atrophy Syndromic Microphthalmia 10 Microphthalmia-Brain Atrophy Syndrome Microphthalmia Syndromic 10 Moba Syndrome Syndromic Microphthalmia Type 10

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11787	RCL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17644	Rcl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24104	Rcl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RCL1	MGD	MGI:1913275
Canis familiaris	RCL1	VGNC	VGNC:45444
Bos taurus	RCL1	VGNC	VGNC:33830
Felis catus	RCL1	VGNC	VGNC:64550
Rattus norvegicus	RCL1	RGD	RGD:1305320
Others	RCL1	NCBI