KCNMB2 - potassium calcium-activated channel subfamily M regulatory beta subunit 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10242

About KCNMB2

Cytogenetic location: 3q26.32 Genomic coordinates (GRCh38): 3:178,536,436-178,844,429 (from NCBI)

This gene has 9 transcripts (splice variants), 263 orthologues and 3 paralogues. Biased expression in ovary (RPKM 5.5), adrenal (RPKM 2.4) and 8 other tissues.

Summary

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]

KCNMB2 Products (3)

mRNA Protein Name
NM_001278911.2 NP_001265840.1 calcium-activated potassium channel subunit beta-2
NM_005832.5 NP_005823.1 calcium-activated potassium channel subunit beta-2
NM_181361.3 NP_852006.1 calcium-activated potassium channel subunit beta-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-activated potassium channel activity IDA
IDA: Inferred from direct assay
10692449 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
Biological Process GO Annotation Evidence References Source
involved in action potential IDA
IDA: Inferred from direct assay
10692449 GOA
involved in detection of calcium ion IDA
IDA: Inferred from direct assay
10692449 GOA
involved in neuronal action potential IDA
IDA: Inferred from direct assay
10692449 GOA
involved in potassium ion transport IDA
IDA: Inferred from direct assay
10692449 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
10692449 GOA
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
10692449 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNMB2 Protein Structure

KcnmB2_inactiv

KcnmB2_inactiv: KCNMB2, ball and chain domain (1 - 32)

CaKB

CaKB: Calcium-activated potassium channel, beta subunit (33 - 230)

  • 0
  • 100
  • 200
  • 235 a.a.
Protein Preferred Names Protein Names

calcium-activated potassium channel subunit beta-2

  • BK channel beta subunit 2

KCNMB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KCNMB2 Q9Y691 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
KCNMB2 Q9Y691 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
KCNMB2 Q9Y691 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07166 KCNMB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07167 KCNMB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus KCNMB2 VGNC VGNC:102763
Rattus norvegicus KCNMB2 RGD RGD:631398
Canis familiaris KCNMB2 VGNC VGNC:54103
Mus musculus KCNMB2 MGD MGI:1919663
Macaca mulatta KCNMB2 VGNC VGNC:84158
Others KCNMB2 NCBI