GLYAT - glycine-N-acyltransferase Gene

Also Known as CAT; GAT; ACGNAT

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10249

About GLYAT

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:58,708,757-58,731,943 (from NCBI)

This gene has 6 transcripts (splice variants), 227 orthologues and 4 paralogues. Biased expression in kidney (RPKM 86.1), liver (RPKM 53.7) and 1 other tissue.

Summary

The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GLYAT Products (2)

mRNA Protein Name
NM_005838.4 NP_005829.3 glycine N-acyltransferase isoform b
NM_201648.3 NP_964011.2 glycine N-acyltransferase isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glycine N-acyltransferase activity IDA
IDA: Inferred from direct assay
22475485 GOA
enables glycine N-benzoyltransferase activity IDA
IDA: Inferred from direct assay
22475485 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in benzoyl-CoA metabolic process IDA
IDA: Inferred from direct assay
22475485 GOA
involved in glycine metabolic process IDA
IDA: Inferred from direct assay
22475485 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
22475485 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLYAT Protein Structure

Gly_acyl_tr_N

Gly_acyl_tr_N: Aralkyl acyl-CoA:amino acid N-acyltransferase (2 - 206)

Gly_acyl_tr_C

Gly_acyl_tr_C: Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region (207 - 295)

  • 0
  • 100
  • 200
  • 296 a.a.
Protein Preferred Names Protein Names

glycine N-acyltransferase

  • AAc

GLYAT Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GLYAT Q6IB77 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra
GLYAT Q6IB77 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
Intra
GLYAT Q6IB77 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Osteogenesis Imperfecta, Type I

  • Osteogenesis Imperfecta Type I

  • OI1

  • Oi, Type I

  • Osteogenesis Imperfecta Tarda

  • Osteogenesis Imperfecta With Blue Sclerae

  • Osteogenesis Imperfecta Type 1

  • Adair-Dighton Syndrome

  • Mild Osteogenesis Imperfecta

  • Non-Deforming Osteogenesis Imperfecta

  • Oi Type 1

  • Van Der Hoeve Syndrome

  • Classic Non-Deforming Oi With Blue Sclerae

  • Osteogenesis Imperfecta 1

  • Oi-I

  • Osteopenic Non-Fracture Syndrome

  • Osteogenesis Imperfecta, Mild

  • Osteogenesis Imperfecta

  • Lobstein'S Disease
Adenosquamous Prostate Carcinoma

  • Adenosquamous Carcinoma Of Prostate

  • Adenosquamous Carcinoma Of The Prostate
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05510 GLYAT Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GLYAT RGD RGD:1307163
Canis familiaris GLYAT VGNC VGNC:97198
Macaca mulatta GLYAT VGNC VGNC:72937
Mus musculus GLYAT MGD MGI:2147502
Others GLYAT NCBI