WFDC2 - WAP four-disulfide core domain 2 Gene

Homo sapiens

Also known as HE4; WAP5; EDDM4; dJ461P17.6

Gene ID: 10406 | Gene type: protein coding

About WFDC2

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,469,753-45,481,532 (from NCBI)

This gene has 7 transcripts (splice variants) and 100 orthologues. Biased expression in salivary gland (RPKM 317.9), endometrium (RPKM 117.3) and 8 other tissues.

Summary

This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]

WFDC2 Products(1)

mRNA	Protein	Name
NM_006103.4	NP_006094.3	WAP four-disulfide core domain protein 2 precursor

WFDC2 Protein Structure

WAP

0
100
124 a.a.

Protein Preferred Names

Protein Names

WAP four-disulfide core domain protein 2

WAP domain containing protein HE4-V4

Recombinant WFDC2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71432	HE4/WFDC2 Protein, Human (HEK293, His)	Q14508 (E31-F124)	≥95%
HY-P78865	HE4/WFDC2 Protein, Human (Biotinylated, HEK293, His-Avi)	Q14508 (E31-F124)	≥95%

Related Diseases

Diseases

Alias

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Malignant Ovarian Cyst

Ovarian Cyst

Ovarian Cysts

Mucinous Ovarian Cystadenoma

Mucinous Cystadenoma Of Ovary

Ovarian Mucinous Cystadenoma

Ovarian Mucinous Cystadenocarcinoma

Mucinous Cystadenocarcinoma Of Ovary

Ovarian Cystadenoma

Cystoma Serosum Simplex	Simple Cystoma Of Ovary
Simple Cystoma Of The Ovary

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15811	WFDC2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	WFDC2	VGNC	VGNC:54267
Rattus norvegicus	WFDC2	RGD	RGD:628757
Macaca mulatta	WFDC2	VGNC	VGNC:78993
Mus musculus	WFDC2	MGD	MGI:1914951
Bos taurus	WFDC2	VGNC	VGNC:36933
Others	WFDC2	NCBI

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