Bap1 - Brca1 associated protein 1 Gene

Also Known as uch-x4; mKIAA0272; 2300006C11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 104416

Summary

Predicted to enable chromatin binding activity and thiol-dependent Deubiquitinase. Acts upstream of or within several processes, including macrophage homeostasis; regulation of cytokine production involved in inflammatory response; and regulation of inflammatory response. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of PR-DUB complex. Predicted to be active in cytoplasm. Is expressed in gonad; liver; and mammary gland. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in basal cell carcinoma and extrahepatic bile duct adenocarcinoma. Orthologous to human BAP1 (BRCA1 associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Bap1 Products (1)

mRNA Protein Name
NM_027088.2 NP_081364.1 ubiquitin carboxyl-terminal hydrolase BAP1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
22878500 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9528852 MGI
Biological Process GO Annotation Evidence References Source
involved in cell population proliferation IMP
IMP: Inferred from mutant phenotype
22878500 MGI
involved in common myeloid progenitor cell proliferation IMP
IMP: Inferred from mutant phenotype
22878500 MGI
involved in erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
22878500 MGI
involved in erythrocyte maturation IMP
IMP: Inferred from mutant phenotype
22878500 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
22878500 MGI
involved in granulocyte differentiation IMP
IMP: Inferred from mutant phenotype
22878500 MGI
involved in hematopoietic stem cell homeostasis IMP
IMP: Inferred from mutant phenotype
22878500 MGI
involved in in utero embryonic development IMP
IMP: Inferred from mutant phenotype
22878500 MGI
involved in leukocyte proliferation IMP
IMP: Inferred from mutant phenotype
22878500 MGI
acts upstream of or within macrophage homeostasis IMP
IMP: Inferred from mutant phenotype
26119930 MGI
involved in mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
22878500 MGI
involved in myeloid cell apoptotic process IMP
IMP: Inferred from mutant phenotype
22878500 MGI
involved in neuron cellular homeostasis IMP
IMP: Inferred from mutant phenotype
22878500 MGI
involved in neutrophil differentiation IMP
IMP: Inferred from mutant phenotype
22878500 MGI
involved in nucleate erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
22878500 MGI
involved in platelet morphogenesis IMP
IMP: Inferred from mutant phenotype
22878500 MGI
acts upstream of or within regulation of cytokine production involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
26119930 MGI
acts upstream of or within regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
26119930 MGI
involved in thrombocyte differentiation IMP
IMP: Inferred from mutant phenotype
22878500 MGI
involved in tissue homeostasis IMP
IMP: Inferred from mutant phenotype
22878500 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase BAP1

  • BRCA1-associated protein 1

  • ubiquitin C-terminal hydrolase X4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W327122 BAP1-IN-1 Inhibitor 99.86% Unkown
HY-158774 TG2-179-1 Inducer 99.0% Unkown
HY-169213 LN-439A Inhibitor / Unkown
HY-N18934 Indigoidine Inhibitor / Unkown
HY-RS01364 BAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07981 MAGI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12074 RNF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16963 Bap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20444 Magi1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23406 Bap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26953 Magi1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bap1 NCBI NCBI:8314