LRRN2 - leucine rich repeat neuronal 2 Gene

Also Known as GAC1; LRRN5; LRANK1; FIGLER7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10446

About LRRN2

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:204,617,170-204,685,738 (from NCBI)

This gene has 4 transcripts (splice variants), 185 orthologues and 25 paralogues. Broad expression in brain (RPKM 5.5), kidney (RPKM 2.6) and 20 other tissues.

Summary

The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with Other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

LRRN2 Products (2)

mRNA Protein Name
NM_006338.3 NP_006329.2 leucine-rich repeat neuronal protein 2 precursor
NM_201630.2 NP_963924.1 leucine-rich repeat neuronal protein 2 precursor

LRRN2 Protein Structure

LRR_6

LRR_6: Leucine Rich repeat (94 - 107)

LRR_8

LRR_8: Leucine rich repeat (117 - 167)

LRR_8

LRR_8: Leucine rich repeat (189 - 249)

LRR_8

LRR_8: Leucine rich repeat (310 - 371)

I-set

I-set: Immunoglobulin I-set domain (430 - 514)

  • 0
  • 200
  • 400
  • 600
  • 713 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat neuronal protein 2

  • fibronectin type III, immunoglobulin and leucine rich repeat domain 7

Related Diseases

Diseases Alias
Tremor, Hereditary Essential, 5

  • ETM5

  • Essential Tremor 5

  • Essential Tremor, Hereditary, 5

  • Hereditary Essential Tremor 5

  • Tremor, Hereditary Essential 5

  • Tremor, Essential Hereditary, Type 5
Tremor, Hereditary Essential, 4

  • ETM4

  • Essential Tremor 4

  • Essential Tremor, Hereditary, 4

  • Hereditary Essential Tremor 4

  • Tremor, Hereditary Essential 4

  • Tremor, Hereditary Essential, Type 4
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07837 LRRN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19456 Lrrn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25949 Lrrn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LRRN2 VGNC VGNC:63311
Bos taurus LRRN2 VGNC VGNC:106808
Mus musculus LRRN2 MGD MGI:106037
Rattus norvegicus LRRN2 RGD RGD:1305482
Canis familiaris LRRN2 VGNC VGNC:42825
Others LRRN2 NCBI