ENTREP3 - endosomal transmembrane epsin interactor 3 Gene

Also Known as COTE1; C1orf2; FAM189B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10712

Summary

This gene is located near the gene for the lysosomal enzyme glucosylceramidase; a deficiency in this enzyme is associated with Gaucher disease. The encoded protein has been identified as a potential binding partner of a WW domain-containing protein which is involved in Apoptosis and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Ubiquitous expression in fat (RPKM 4.9), testis (RPKM 4.8) and 25 other tissues.

ENTREP3 Products (3)

mRNA Protein Name
NM_001267608.2 NP_001254537.1 protein ENTREP3 isoform c
NM_006589.3 NP_006580.2 protein ENTREP3 isoform a
NM_198264.2 NP_937995.1 protein ENTREP3 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables WW domain binding IPI
IPI: Inferred from physical interaction
15064722 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15064722 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENTREP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
ENTREP3 P81408 WWOX Homo sapiens Q9NZC7
Protein Array
15064722
Intra
ENTREP3 P81408 WWOX Homo sapiens Q9NZC7
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction