Ankrd1 - ankyrin repeat domain 1 (cardiac muscle) Gene

Also Known as Alrp; CARP; Crap; MARP1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 107765

Summary

Enables titin binding activity and transcription corepressor activity. Involved in cellular response to lipopolysaccharide and cellular response to xenobiotic stimulus. Acts upstream of or within protein kinase C signaling; regulation of transcription by RNA polymerase II; and skeletal muscle cell differentiation. Located in I band and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; heart; male reproductive gland or organ; skeletal musculature; and somite. Human ortholog(s) of this gene implicated in congenital structural myopathy; dilated cardiomyopathy; hypertrophic cardiomyopathy; nemaline myopathy; and spinal muscular atrophy. Orthologous to human ANKRD1 (ankyrin repeat domain 1). [provided by Alliance of Genome Resources, Apr 2022]

Ankrd1 Products (1)

mRNA Protein Name
NM_013468.3 NP_038496.2 ankyrin repeat domain-containing protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14741210 MGI
enables titin binding IPI
IPI: Inferred from physical interaction
18310072 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
9043061 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
17239933 MGI
involved in cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
17239933 MGI
acts upstream of or within phospholipase C/protein kinase C signal transduction IGI
IGI: Inferred from genetic interaction
27353086 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9043061 MGI
acts upstream of or within skeletal muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
22147266 MGI
Cellular Component GO Annotation Evidence References Source
located in I band IDA
IDA: Inferred from direct assay
11309420 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
9382869 MGI
located in myofibril IDA
IDA: Inferred from direct assay
18310072 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9382869 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
27353086 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
9043061 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ankyrin repeat domain-containing protein 1

  • ankyrin-like repeat protein

  • cardiac ankyrin repeat protein

  • cardiac responsive adriamycin protein

Ankrd1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ankrd1 Q9CR42 Ncl Mus musculus P09405
Anti Bait CoIP
24515436
Intra
Ankrd1 Q9CR42 Ncl Mus musculus P09405
Y2H
24515436
Intra
Ankrd1 Q9CR42 Ncl Mus musculus P09405
Anti Tag CoIP
24515436
Intra
Ankrd1 Q9CR42 Ncl Mus musculus P09405
IF
24515436
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00712 ANKRD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19764 Ankrd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26261 Ankrd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ankrd1 NCBI NCBI:27063