Mthfd1 - methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase Gene

Also Known as Dcs; Mthfd; E430024A07Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 108156

Summary

This gene encodes a trifunctional cytoplasmic enzyme. The encoded protein functions as a methylenetetrahydrofolate dehydrogenase, a methenyltetrahydrofolate cyclohydrolase, and a formyltetrahydrofolate synthase. The encoded enzyme functions in de novo synthesis of purines and thymidylate and in regeneration of methionine from homocysteine. [provided by RefSeq, Oct 2009]

Mthfd1 Products (1)

mRNA	Protein	Name
NM_138745.2	NP_620084.2	C-1-tetrahydrofolate synthase, cytoplasmic

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables formate-tetrahydrofolate ligase activity	IMP IMP: Inferred from mutant phenotype	15611115	MGI
enables methylenetetrahydrofolate dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	23704330	MGI
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity	IMP IMP: Inferred from mutant phenotype	15611115	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in 10-formyltetrahydrofolate biosynthetic process	IMP IMP: Inferred from mutant phenotype	23704330	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	23704330	MGI
involved in methionine metabolic process	IMP IMP: Inferred from mutant phenotype	23190757	MGI
involved in neural tube closure	IMP IMP: Inferred from mutant phenotype	23704330	MGI
involved in neutrophil homeostasis	IMP IMP: Inferred from mutant phenotype	23704330	MGI
involved in purine nucleotide biosynthetic process	IMP IMP: Inferred from mutant phenotype	23704330	MGI
acts upstream of purine ribonucleotide biosynthetic process	IMP IMP: Inferred from mutant phenotype	15611115	MGI
involved in serine family amino acid metabolic process	IMP IMP: Inferred from mutant phenotype	23190757	MGI
involved in somite development	IMP IMP: Inferred from mutant phenotype	23704330	MGI
involved in tetrahydrofolate interconversion	IMP IMP: Inferred from mutant phenotype	23704330	MGI
involved in transsulfuration	IMP IMP: Inferred from mutant phenotype	23190757	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
C-1-tetrahydrofolate synthase, cytoplasmic	C1-THF synthase C1-tetrahydrofolate synthase

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-155950	TH9619		99.33%	Phase 2

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-130251	DS18561882		99.95%	Unkown
HY-101943	LY 345899		98.0%	Unkown
HY-131943	DS44960156	Inhibitor	≥99.0%	Unkown
HY-155219	TH9028		/	Unkown
HY-149825	MTHFD2-IN-1	Inhibitor	/	Unkown
HY-149826	MTHFD2-IN-2	Inhibitor	/	Unkown
HY-149827	MTHFD2-IN-3	Inhibitor	/	Unkown
HY-149828	MTHFD2-IN-4	Inhibitor	/	Unkown
HY-149828A	MTHFD2-IN-4 sodium	Inhibitor	/	Unkown
HY-170361	MTHFD2-IN-5	Inhibitor	/	Unkown
HY-172910	MTHFD2-IN-6		/	Unkown
HY-182355	MTHFD2-IN-7	Inhibitor	/	Unkown
HY-182356	MTHFD1/2-IN-1	Inhibitor	/	Unkown
HY-RS08774	MTHFD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08775	MTHFD1L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-148014	TH7299		/	Unkown
HY-RS17098	Mthfd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20214	Mthfd1l Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23542	Mthfd1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26720	Mthfd1l Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mthfd1	NCBI	NCBI:4522