GADD45G - growth arrest and DNA damage inducible gamma Gene

Also Known as CR6; DDIT2; GRP17; GADD45gamma

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10912

About GADD45G

Cytogenetic location: 9q22.2 Genomic coordinates (GRCh38): 9:89,605,012-89,606,555 (from NCBI)

This gene has 3 transcripts (splice variants), 343 orthologues and 2 paralogues. Broad expression in liver (RPKM 21.4), placenta (RPKM 16.8) and 22 other tissues.

Summary

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]

GADD45G Products (1)

mRNA Protein Name
NM_006705.4 NP_006696.1 growth arrest and DNA damage-inducible protein GADD45 gamma

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12052864 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
9827804 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
9827804 GOA
involved in positive regulation of p38MAPK cascade IDA
IDA: Inferred from direct assay
9827804 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9827804 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9827804 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GADD45G Protein Structure

Ribosomal_L7Ae

Ribosomal_L7Ae: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family (25 - 107)

  • 0
  • 100
  • 159 a.a.
Protein Preferred Names Protein Names

growth arrest and DNA damage-inducible protein GADD45 gamma

  • DDIT-2

GADD45G Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GADD45G O95257 BEND7 Homo sapiens Q8N7W2-2
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 BEND7 Homo sapiens Q8N7W2-2
Validated Y2H
32296183
Intra
GADD45G O95257 BEND7 Homo sapiens Q8N7W2-2
Y2H Array
32296183
Intra
GADD45G O95257 CEP57L1 Homo sapiens Q8IYX8-2
Validated Y2H
25416956
Intra
GADD45G O95257 CEP57L1 Homo sapiens Q8IYX8-2
Y2H Prey Pooling
25416956
Intra
GADD45G O95257 ZNF763 Homo sapiens Q0D2J5
Validated Y2H
32296183
Intra
GADD45G O95257 ZNF763 Homo sapiens Q0D2J5
Y2H Array
32296183
Intra
GADD45G O95257 ZNF763 Homo sapiens Q0D2J5
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 AFAP1L1 Homo sapiens Q8TED9
Y2H Prey Pooling
25416956
Intra
GADD45G O95257 AFAP1L1 Homo sapiens Q8TED9
Y2H Array
25416956
Intra
GADD45G O95257 AFAP1L1 Homo sapiens Q8TED9
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 AFAP1L1 Homo sapiens Q8TED9
Y2H Array
31515488
Intra
GADD45G O95257 AFAP1L1 Homo sapiens Q8TED9
Validated Y2H
32296183
Intra
GADD45G O95257 AFAP1L1 Homo sapiens Q8TED9
Y2H Array
32296183
Intra
GADD45G O95257 GRAMD4 Homo sapiens Q6IC98
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 GRAMD4 Homo sapiens Q6IC98
Y2H Array
32296183
Intra
GADD45G O95257 GRAMD4 Homo sapiens Q6IC98
Validated Y2H
32296183
Intra
GADD45G O95257 NMB Homo sapiens P08949-2
Validated Y2H
32296183
Intra
GADD45G O95257 NMB Homo sapiens P08949-2
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 NMB Homo sapiens P08949-2
Y2H Array
32296183
Intra
GADD45G O95257 CFAP44 Homo sapiens Q96MT7
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 CFAP44 Homo sapiens Q96MT7
Y2H Array
32296183
Intra
GADD45G O95257 CNOT9 Homo sapiens Q92600-3
Validated Y2H
32296183
Intra
GADD45G O95257 CNOT9 Homo sapiens Q92600-3
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 CNOT9 Homo sapiens Q92600-3
Y2H Array
32296183
Intra
GADD45G O95257 TSNAX Homo sapiens Q99598
Validated Y2H
32296183
Intra
GADD45G O95257 TSNAX Homo sapiens Q99598
Y2H Array
32296183
Intra
GADD45G O95257 TSNAX Homo sapiens Q99598
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 ZNF664 Homo sapiens Q8N3J9
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 ZNF664 Homo sapiens Q8N3J9
Validated Y2H
32296183
Intra
GADD45G O95257 ZNF664 Homo sapiens Q8N3J9
Y2H Array
32296183
Intra
GADD45G O95257 ACTN1 Homo sapiens P12814
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 ACTN1 Homo sapiens P12814
Y2H Array
32296183
Intra
GADD45G O95257 ACTN1 Homo sapiens P12814
Validated Y2H
32296183
Intra
GADD45G O95257 GADD45GIP1 Homo sapiens Q8TAE8
Anti Tag CoIP
12716909
Intra
GADD45G O95257 GADD45GIP1 Homo sapiens Q8TAE8
Y2H
12716909
Intra
GADD45G O95257 MED31 Homo sapiens Q9Y3C7
Y2H
15383276
Intra
GADD45G O95257 KAT5 Homo sapiens Q92993
Pull Down
15383276
Intra
GADD45G O95257 MAP3K4 Homo sapiens Q9Y6R4
DHFR Reconstruction
12052864
Intra
GADD45G O95257 MAP3K4 Homo sapiens Q9Y6R4
Anti Tag CoIP
33961781
Intra
GADD45G O95257 BLOC1S2 Homo sapiens Q6QNY1
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 BLOC1S2 Homo sapiens Q6QNY1
Y2H Array
32296183
Intra
GADD45G O95257 BLOC1S2 Homo sapiens Q6QNY1
Validated Y2H
32296183
Intra
GADD45G O95257 CEP126 Homo sapiens Q9P2H0
Y2H
15383276
Intra
GADD45G O95257 CEP126 Homo sapiens Q9P2H0
Pull Down
15383276
Intra
GADD45G O95257 LRIF1 Homo sapiens Q5T3J3
Validated Y2H
32296183
Intra
GADD45G O95257 LRIF1 Homo sapiens Q5T3J3
Y2H
15383276
Intra
GADD45G O95257 LRIF1 Homo sapiens Q5T3J3
Y2H Array
32296183
Intra
GADD45G O95257 LRIF1 Homo sapiens Q5T3J3
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 UTP14A Homo sapiens Q9BVJ6
Pull Down
15383276
Intra
GADD45G O95257 RASSF10 Homo sapiens A6NK89
Y2H Array
32296183
Intra
GADD45G O95257 RASSF10 Homo sapiens A6NK89
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 ARPC5L Homo sapiens Q9BPX5
Y2H
21988832
Intra
GADD45G O95257 ARPC5L Homo sapiens Q9BPX5
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 ARPC5L Homo sapiens Q9BPX5
Validated Y2H
32296183
Intra
GADD45G O95257 ARPC5L Homo sapiens Q9BPX5
Y2H Array
32296183
Intra
GADD45G O95257 DCTN2 Homo sapiens Q13561
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 DCTN2 Homo sapiens Q13561
Validated Y2H
32296183
Intra
GADD45G O95257 DCTN2 Homo sapiens Q13561
Y2H Array
32296183
Intra
GADD45G O95257 RRP7A Homo sapiens Q9Y3A4
Y2H Array
32296183
Intra
GADD45G O95257 RRP7A Homo sapiens Q9Y3A4
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 RRP7A Homo sapiens Q9Y3A4
Validated Y2H
32296183
Intra
GADD45G O95257 RWDD2B Homo sapiens P57060
Validated Y2H
32296183
Intra
GADD45G O95257 RWDD2B Homo sapiens P57060
Y2H Array
32296183
Intra
GADD45G O95257 RWDD2B Homo sapiens P57060
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 RWDD2B Homo sapiens P57060
Validated Y2H
25416956
Intra
GADD45G O95257 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
GADD45G O95257 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
GADD45G O95257 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
GADD45G O95257 ENKD1 Homo sapiens Q9H0I2
Y2H Array
32296183
Intra
GADD45G O95257 ENKD1 Homo sapiens Q9H0I2
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 FAM156B Homo sapiens Q8NDB6
Validated Y2H
32296183
Intra
GADD45G O95257 FAM156B Homo sapiens Q8NDB6
Y2H Array
32296183
Intra
GADD45G O95257 FAM156B Homo sapiens Q8NDB6
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 RCN1 Homo sapiens Q15293
Y2H Array
32296183
Intra
GADD45G O95257 RCN1 Homo sapiens Q15293
Y2H Prey Pooling
32296183
Intra
GADD45G O95257 RCN1 Homo sapiens Q15293
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GADD45G Proteins

Cat. No. Product Name Accession Purity
HY-P70218 GADD45G/DDIT2 Protein, Human (His) O95257 (M1-E159) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Pituitary Adenoma

  • Adenoma Of The Pituitary Gland

  • Pituitary Adenomas

  • Adenoma, Pituitary

  • Pituitary Gland Adenoma

  • Pituitary Neoplasms
Retinal Microaneurysm

  • Microaneurysm
Severe Nonproliferative Diabetic Retinopathy

  • High Risk Non Proliferative Diabetic Retinopathy

  • Severe Npdr
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Background Diabetic Retinopathy

  • Non Proliferative Diabetic Retinopathy

  • Non-Proliferative Diabetic Retinopathy

  • Nonproliferative Diabetic Retinopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05231 GADD45G Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19838 Gadd45g Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26335 Gadd45g Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GADD45G VGNC VGNC:103268
Bos taurus GADD45G VGNC VGNC:29208
Felis catus GADD45G VGNC VGNC:102932
Canis familiaris GADD45G VGNC VGNC:41071
Rattus norvegicus GADD45G RGD RGD:1311796
Mus musculus GADD45G MGD MGI:1346325
Others GADD45G NCBI