SPIN1 - spindlin 1 Gene

Also Known as SPIN; TDRD24

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10927

About SPIN1

Cytogenetic location: 9q22.1 Genomic coordinates (GRCh38): 9:88,388,444-88,478,694 (from NCBI)

This gene has 6 transcripts (splice variants), 271 orthologues and 4 paralogues. Ubiquitous expression in endometrium (RPKM 40.9), brain (RPKM 36.4) and 25 other tissues.

Summary

Enables methylated histone binding activity. Involved in positive regulation of Wnt signaling pathway; positive regulation of transcription, DNA-templated; and rRNA transcription. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SPIN1 Products (1)

mRNA Protein Name
NM_006717.3 NP_006708.2 spindlin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables methylated histone binding IDA
IDA: Inferred from direct assay
21029866 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24589551 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
29061846 GOA
involved in positive regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
24589551 GOA
involved in rRNA transcription IDA
IDA: Inferred from direct assay
21960006 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleolus IDA
IDA: Inferred from direct assay
21960006 GOA
located in nucleus IDA
IDA: Inferred from direct assay
29061846 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPIN1 Protein Structure

Spin-Ssty

Spin-Ssty: Spin/Ssty Family (54 - 102)

Spin-Ssty

Spin-Ssty: Spin/Ssty Family (133 - 182)

Spin-Ssty

Spin-Ssty: Spin/Ssty Family (214 - 259)

  • 0
  • 100
  • 200
  • 262 a.a.
Protein Preferred Names Protein Names

spindlin-1

  • ovarian cancer-related protein

SPIN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SPIN1 Q9Y657 HSPB1 Homo sapiens P04792
Anti Bait CoIP
25277244
Cross: Cross-species interaction Intra: Intraspecies interaction

SPIN1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811100 SPIN1 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Acquired Color Blindness

  • Acquired Color Vision Deficiencies

  • Acquired Color Vision Deficiency

  • Acquired Colour Blindness

  • Acquired Colour Vision Deficiencies

  • Acquired Colour Vision Deficiency
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Shoulder Impingement Syndrome

  • Impingement Syndrome Of Shoulder Region

  • Subacromial Impingement
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125837A MS31 trihydrochloride Inhibitor 98.0% Unkown
HY-RS13675 SPIN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-125837 MS31 Inhibitor / Unkown
HY-121511 EML631 Inhibitor / Unkown
HY-163460 MS8535 Inhibitor / Unkown
HY-RS13690 SPNS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-161068 hACE2/SP-IN-1 Inhibitor / Unkown
HY-RS22825 Spin1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29340 Spin1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SPIN1 VGNC VGNC:77859
Mus musculus SPIN1 MGD MGI:109242
Felis catus SPIN1 VGNC VGNC:102985
Rattus norvegicus SPIN1 RGD RGD:1306210
Bos taurus SPIN1 VGNC VGNC:35217
Canis familiaris SPIN1 VGNC VGNC:46742
Others SPIN1 NCBI