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MS8535 is a SPIN1 selective inhibitor, with an IC50 of 0.2 μM.

For research use only. We do not sell to patients.

MS8535 Chemical Structure

MS8535 Chemical Structure

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MS8535 Related Antibodies

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Description

MS8535 is a SPIN1 selective inhibitor, with an IC50 of 0.2 μM[1].

In Vitro

MS8535 (compound 18, 0-10 μM) concentration dependently blocks the interactions between SPIN1 and histone H3 in U2OS cells with an EC50 of 1.1 ± 0.3 μM (n = 2)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MS8535 Related Antibodies
In Vivo

MS8535 (compound 18, 5 mg/kg, ip) is well tolerated by the treated mice and no clinical signs are observed in the PK study[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

490.64

Formula

C28H38N6O2
SMILES

COC1=CC2=C(C=C1OCCCN3CC4=C(C3)C=CC=C4)N=C(NCCN(C)C)N=C2N5CCCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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MS8535 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS8535MS 8535MS-8535OthersSPIN1well toleratedU2OS cellInhibitorinhibitorinhibit

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