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Cat. No.: HY-163460

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MS8535

MS8535 is a SPIN1 selective inhibitor, with an IC₅₀ of 0.2 μM.

For research use only. We do not sell to patients.

CAS No.: 3060589-97-8
Formula: C₂₈H₃₈N₆O₂
Molecular Weight:490.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (240 KB)

MS8535 Chemical Structure

CAS No.: 3060589-97-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Protocols (1)
Purity & Documentation
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

MS8535 is a SPIN1 selective inhibitor, with an IC₅₀ of 0.2 μM^[1].

All Epigenetic Reader Domain Isoforms :

In Vitro

MS8535 (compound 18, 0-10 μM) concentration dependently blocks the interactions between SPIN1 and histone H3 in U2OS cells with an EC₅₀ of 1.1 ± 0.3 μM (n = 2)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

In Vivo

MS8535 (compound 18, 5 mg/kg, ip) is well tolerated by the treated mice and no clinical signs are observed in the PK study^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3060589-97-8
Molecular Weight 490.64
Formula C₂₈H₃₈N₆O₂
SMILES

COC1=CC2=C(C=C1OCCCN3CC4=C(C3)C=CC=C4)N=C(NCCN(C)C)N=C2N5CCCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (240 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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