SERINC3 - serine incorporator 3 Gene

Also Known as TDE; TDE1; AIGP1; TMS-1; DIFF33; SBBI99

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10955

About SERINC3

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:44,496,221-44,522,070 (from NCBI)

This gene has 4 transcripts (splice variants), 214 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 33.6), testis (RPKM 32.1) and 25 other tissues.

Summary

Predicted to enable L-serine transmembrane transporter activity. Involved in defense response to virus; detection of virus; and innate immune response. Predicted to be located in Golgi apparatus. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]

SERINC3 Products (2)

mRNA Protein Name
NM_006811.4 NP_006802.1 serine incorporator 3 precursor
NM_198941.3 NP_945179.1 serine incorporator 3 precursor

SERINC3 Protein Structure

Serinc

Serinc: Serine incorporator (Serinc) (16 - 472)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 473 a.a.
Protein Preferred Names Protein Names

serine incorporator 3

  • tumor differentially expressed protein 1

SERINC3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SERINC3 Q13530 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
SERINC3 Q13530 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
SERINC3 Q13530 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
SERINC3 Q13530 PEX1 Homo sapiens O43933
Validated Y2H
32814053
Intra
SERINC3 Q13530 PEX1 Homo sapiens O43933
Y2H Pooling
32814053
Intra
SERINC3 Q13530 PEX1 Homo sapiens O43933
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spastic Paraplegia 50, Autosomal Recessive

  • Hereditary Spastic Paraplegia 50

  • SPG50

  • Ap-4 Deficiency Syndrome

  • Ap-4-Associated Hereditary Spastic Paraplegia

  • Adaptor Protein Complex 4 Deficiency

  • Cerebral Palsy, Spastic Quadriplegic, 3, Formerly

  • Cpsq3, Formerly

  • Autosomal Recessive Spastic Paraplegia 50

  • Cpsq3

  • Spastic Quadriplegic Cerebral Palsy 3

  • Ap-4 Deficiency

  • Ap-4-Associated Hsp

  • Paraplegia, Spastic, Autosomal Recessive, Type 50

  • Spastic Paraplegia-50, Autosomal Recessive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12692 SERINC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SERINC3 RGD RGD:1308390
Macaca mulatta SERINC3 VGNC VGNC:77222
Mus musculus SERINC3 MGD MGI:1349457
Canis familiaris SERINC3 VGNC VGNC:46021
Felis catus SERINC3 VGNC VGNC:65019
Bos taurus SERINC3 VGNC VGNC:34462
Others SERINC3 NCBI