ACOT2 - acyl-CoA thioesterase 2 Gene

Also Known as MTE1; PTE2; CTE1A; PTE2A; CTE-IA; ZAP128

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10965

About ACOT2

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:73,567,620-73,575,658 (from NCBI)

This gene has 4 transcripts (splice variants), 436 orthologues and 4 paralogues. Broad expression in fat (RPKM 57.3), liver (RPKM 39.8) and 21 other tissues.

Summary

This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

ACOT2 Products (3)

mRNA Protein Name
NM_001364177.1 NP_001351106.1 acyl-coenzyme A thioesterase 2, mitochondrial isoform 2
NM_001364178.1 NP_001351107.1 acyl-coenzyme A thioesterase 2, mitochondrial isoform 3
NM_006821.6 NP_006812.3 acyl-coenzyme A thioesterase 2, mitochondrial isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables fatty acyl-CoA hydrolase activity IDA
IDA: Inferred from direct assay
10944470 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25464930 GOA
Biological Process GO Annotation Evidence References Source
involved in acyl-CoA metabolic process IDA
IDA: Inferred from direct assay
10944470 GOA
involved in long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
16940157 GOA
involved in very long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
16940157 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
16940157 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACOT2 Protein Structure

Bile_Hydr_Trans

Bile_Hydr_Trans: Acyl-CoA thioester hydrolase/BAAT N-terminal region (77 - 203)

BAAT_C

BAAT_C: BAAT / Acyl-CoA thioester hydrolase C terminal (266 - 473)

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  • 400
  • 483 a.a.
Protein Preferred Names Protein Names

acyl-coenzyme A thioesterase 2, mitochondrial

  • acyl-coenzyme A thioester hydrolase 2a

ACOT2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ACOT2 P49753 NLGN3 Homo sapiens Q9NZ94-2
Anti Tag CoIP
25464930
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00177 ACOT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22372 Acot2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28895 Acot2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ACOT2 MGD MGI:2159605
Rattus norvegicus ACOT2 RGD RGD:621055