Arrb1 - arrestin, beta 1 Gene

Also Known as 1200006I17Rik; G430100A01Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 109689

Summary

Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process and mitogen-activated protein kinase kinase binding activity. Involved in several processes, including negative regulation of Notch signaling pathway; positive regulation of cell communication; and regulation of cellular protein metabolic process. Acts upstream of or within phototransduction and regulation of G protein-coupled receptor signaling pathway. Located in cytosol and pseudopodium. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver; and respiratory system. Orthologous to human ARRB1 (Arrestin beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Arrb1 Products (2)

mRNA	Protein	Name
NM_177231.2	NP_796205.1	beta-arrestin-1 isoform A
NM_178220.3	NP_835738.1	beta-arrestin-1 isoform B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	19915011	MGI
enables mitogen-activated protein kinase kinase binding	IDA IDA: Inferred from direct assay	19915011	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11546805	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	23886940	MGI
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	19915011	MGI
acts upstream of or within phototransduction	IMP IMP: Inferred from mutant phenotype	11853756	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	19915011	MGI
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	19915011	MGI
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	19915011	MGI
involved in positive regulation of protein binding	IMP IMP: Inferred from mutant phenotype	19915011	MGI
acts upstream of or within regulation of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9400383	MGI
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19915011	MGI
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	23886940	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	19915011	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	11171997	MGI
located in pseudopodium	IDA IDA: Inferred from direct assay	12821670	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
beta-arrestin-1	beta-arrestin1

Arrb1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Arrb1	Q8BWG8	Mdm2	Mus musculus	P23804	Y2H	15102471
Intra	Arrb1	Q8BWG8	Hax1	Mus musculus	O35387	Y2H	15102471
Intra	Arrb1	Q8BWG8	Dnajb6	Mus musculus	O54946	Y2H	15102471
Intra	Arrb1	Q8BWG8	Nfe2l2	Mus musculus	Q60795	Y2H	15102471
Intra	Arrb1	Q8BWG8	Card10	Mus musculus	P58660	Anti Tag CoIP	18952848

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01028	ARRB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18162	Arrb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24636	Arrb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arrb1	NCBI	NCBI:408