2. Gene
  3. ARRB1 - arrestin beta 1 Gene

ARRB1 - arrestin beta 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ARB1; ARR1

Gene ID: 408 | Gene type: protein coding

About ARRB1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:75,260,122-75,351,661 (from NCBI)

This gene has 12 transcripts (splice variants), 203 orthologues and 3 paralogues. Broad expression in brain (RPKM 24.0), lung (RPKM 19.9) and 24 other tissues.

Summary

Members of Arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as Hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of Arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]

ARRB1 Products(2)

mRNA Protein Name
NM_004041.5 NP_004032.2 beta-arrestin-1 isoform A
NM_020251.4 NP_064647.1 beta-arrestin-1 isoform B

ARRB1 Protein Structure

Arrestin_N

Arrestin_N: Arrestin (or S-antigen), N-terminal domain (19 - 174)

Arrestin_C

Arrestin_C: Arrestin (or S-antigen), C-terminal domain (194 - 356)

  • 0
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  • 200
  • 300
  • 418 a.a.
Protein Preferred Names Protein Names

beta-arrestin-1

arrestin 2

Recombinant ARRB1 Proteins

Cat. No. Product Name Accession Purity
HY-P7606 ARRB1/Beta-Arrestin 1 Protein, Human (His) P49407 (M1-R418) ≥95%

Related Diseases

Diseases Alias
Placenta Praevia

Placenta Previa

Haemorrhage From Placenta Previa

Placenta Previa Haemorrhage

Lateral Placenta

Low Implantation Of Placenta Nos Or With Haemorrhage

Total Placenta Previa

Total Placenta Praevia Nos Or With Haemorrhage

Placental Previa Haemorrhage

Pp - [Placenta Previa]

Placenta Previa Marginalis

Placenta Previa Partialis

Partial Placenta Previa

Placenta Previa Centralis

Low Implantation Of Placenta

Low Implantation Or Insertion Of Placenta

Low Insertion Of Placenta

Low Lying Placenta

Marginal Placenta

Marginal Placenta Praevia Nos Or With Haemorrhage

Marginal Placenta Previa

Marginal Placental Haemorrhage

Partial Placenta Praevia Nos Or With Haemorrhage
Nephrogenic Syndrome Of Inappropriate Antidiuresis

NSIAD
Precocious Puberty, Central, 1

CPPB1

Central Precocious Puberty 1

Precocious Puberty, Central 1

Puberty, Precocious, Central, Type 1
Whim Syndrome 1

Whim Syndrome

Whims

Warts, Hypogammaglobulinemia, Infections, And Myelokathexis

WHIMS1

Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome

Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1

Myelokathexis, Isolated

Wilm

Warts-Infections-Leukopenia-Myelokatexis Syndrome

Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1
Placental Abruption

Abruptio Placentae

Abruptio Placenta

Abortion, Threatened

Threatened Miscarriage

Haemorrhage Specified As Due To Threatened Abortion

Spontaneous Threatened Abortion
Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Malignant Secondary Hypertension
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01028 ARRB1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ARRB1 MGD MGI:99473
Bos taurus ARRB1 VGNC VGNC:26169
Macaca mulatta ARRB1 VGNC VGNC:70021
Felis catus ARRB1 VGNC VGNC:68263
Rattus norvegicus ARRB1 RGD RGD:2156
Canis familiaris ARRB1 VGNC VGNC:38136
Others ARRB1 NCBI