F11 - coagulation factor XI Gene

Also Known as FXI; PTA; Cf11; 1600027G01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 109821

Summary

This gene encodes a glycoprotein coagulation factor that plays an important role in intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that can be activated by coagulation factor XIIa, Thrombin or factor XIa to generate active factor XIa protease. Mice lacking the encoded protein display a survival advantage during peritoneal sepsis and resist inflammation and Bacterial accumulation upon Infection with Listeria. [provided by RefSeq, Apr 2015]

F11 Products (2)

mRNA Protein Name
NM_001411665.1 NP_001398594.1 coagulation factor XI isoform 2
NM_028066.3 NP_082342.1 coagulation factor XI isoform 1 preproprotein

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence Referencias Source
acts upstream of or within regulation of blood coagulation IMP
IMP: Inferred from mutant phenotype
16533887 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

coagulation factor XI

  • plasma thromboplastin antecedent

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Referencia número Nombre del producto Efecto
Pureza Phase
HY-P991124 Cenvacibart Ligand 99% Phase 3

Pre-clinical Phase

Bioactive Molecules (16)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-162065 N6F11 Inducer 98.11% Unkown
HY-N0541 Pseudoginsenoside F11 99.87% Unkown
HY-124084A SW203668 TFA Inhibitor 99.79% Unkown
HY-N6650 Isotanshinone IIA 98.0% Unkown
HY-RS04626 F11R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-114606 SW208108 Inhibitor / Unkown
HY-124084 SW203668 Inhibitor / Unkown
HY-19606 Cytogenin Inhibitor / Unkown
HY-RS03478 CYP4F11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04625 F11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W143313 1,2-Heptanediol 98.0% Unkown
HY-RS17241 F11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19600 F11r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23695 F11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26096 F11r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W472509 11-HETE Activator / Unkown
Inhibitory Antibodies (3)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-P991761 Anti-Mouse CXCL10 Antibody (1F11) Inhibitor 97.564% Unkown
HY-P991608 CTM01 Inhibitor / Unkown
HY-P991757 Anti-Human/Mouse/Rat/Canine/Swine PSMA Antibody (3F11) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens F11 NCBI NCBI:2160