CHAD - chondroadherin Gene

Also Known as SLRR4A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1101

About CHAD

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,464,496-50,468,880 (from NCBI)

This gene has 3 transcripts (splice variants), 167 orthologues and 22 paralogues. Broad expression in small intestine (RPKM 4.5), liver (RPKM 4.4) and 24 other tissues.

Summary

Chondroadherin is a cartilage matrix protein thought to mediate adhesion of isolated chondrocytes. The protein contains 11 leucine-rich repeats flanked by cysteine-rich regions. The chondroadherin messenger RNA is present in chondrocytes at all ages. [provided by RefSeq, Jul 2008]

CHAD Products (1)

mRNA Protein Name
NM_001267.3 NP_001258.2 chondroadherin precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHAD Protein Structure

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (22 - 48)

LRR_6

LRR_6: Leucine Rich repeat (74 - 90)

LRR_8

LRR_8: Leucine rich repeat (101 - 159)

LRR_8

LRR_8: Leucine rich repeat (196 - 241)

LRR_1

LRR_1: Leucine Rich Repeat (270 - 287)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
Protein Preferred Names Protein Names

chondroadherin

  • cartilage leucine-rich protein

CHAD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CHAD O15335 CNPY4 Homo sapiens Q8N129
Anti Tag CoIP
28514442
Intra
CHAD O15335 CNPY4 Homo sapiens Q8N129
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Epilepsy, Idiopathic Generalized 17

  • Febrile Seizures, Familial, 2

  • EIG17

  • Familial Febrile Seizures 2

  • FEB2

  • Epilepsy, Idiopathic Generalized, Susceptibility To, 17

  • Familial Febrile Convulsions 2

  • Convulsions, Familial Febrile, 2
Calcific Tendinitis

  • Calcific Tendinitis Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02592 CHAD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18029 Chad Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24503 Chad Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CHAD VGNC VGNC:27264
Rattus norvegicus CHAD RGD RGD:2336
Macaca mulatta CHAD VGNC VGNC:71023
Felis catus CHAD VGNC VGNC:60834
Canis familiaris CHAD VGNC VGNC:39187
Mus musculus CHAD MGD MGI:1096866
Others CHAD NCBI