2. Gene
  3. BTN3A1 - butyrophilin subfamily 3 member A1 Gene

BTN3A1 - butyrophilin subfamily 3 member A1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as BTF5; BT3.1; CD277; BTN3.1

Gene ID: 11119 | Gene type: protein coding

About BTN3A1

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,402,275-26,415,208 (from NCBI)

This gene has 11 transcripts (splice variants), 66 orthologues and 15 paralogues. Ubiquitous expression in spleen (RPKM 25.4), lymph node (RPKM 18.1) and 24 other tissues.

Summary

The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]

BTN3A1 Products(4)

mRNA Protein Name
NM_001145008.2 NP_001138480.1 butyrophilin subfamily 3 member A1 isoform c precursor
NM_001145009.2 NP_001138481.1 butyrophilin subfamily 3 member A1 isoform d precursor
NM_007048.6 NP_008979.3 butyrophilin subfamily 3 member A1 isoform a precursor
NM_194441.3 NP_919423.1 butyrophilin subfamily 3 member A1 isoform b precursor

BTN3A1 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (31 - 134)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (164 - 226)

PRY

PRY: SPRY-associated domain (342 - 390)

SPRY

SPRY: SPRY domain (392 - 498)

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  • 513 a.a.
Protein Preferred Names Protein Names

butyrophilin subfamily 3 member A1

dJ45P21.3 (butyrophilin, subfamily 3, member A1)

Recombinant BTN3A1 Proteins

Cat. No. Product Name Accession Purity
HY-P7683 BTN3A1/CD277 Protein, Human (225a.a, HEK293, Fc) O00481 (Q30-G254) ≥95%
HY-P72763 BTN3A1/CD277 Protein, Human (225a.a, HEK293, His) O00481 (Q30-G254) ≥95%
HY-P72345 BTN3A1/CD277 Protein, Human (Biotinylated, HEK293, Fc-Avi) O00481 (Q30-G254) ≥95%
HY-P76179 BTN3A1/CD277 Protein, Human (HEK293) O00481 (Q30-G254) ≥95%
HY-P76180 BTN3A1/CD277 Protein, Human (254a.a, HEK293, Fc) A8K547 (M1-G254) ≥95%
HY-P76181 BTN3A1/CD277 Protein, Human (254a.a, HEK293, His) A8K547 (M1-G254) ≥95%
HY-P76182 BTN3A1/CD277 Protein, Human (Biotinylated, HEK293, His) O00481 (Q30-G254) ≥95%
HY-P78079 BTN3A1/CD277 Protein, Human (Biotinylated, 225a.a, HEK293, His) O00481 (Q30-G254) ≥95%
HY-P78080 BTN3A1/CD277 Protein, Human (Biotinylated, HEK293, His-Avi) O00481 (Q30-G254) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01673 BTN3A1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca fascicularis BTN3A1 NCBI