BTN3A1 - butyrophilin subfamily 3 member A1 Gene

Also Known as BTF5; BT3.1; CD277; BTN3.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11119

About BTN3A1

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,402,275-26,415,208 (from NCBI)

This gene has 11 transcripts (splice variants), 66 orthologues and 15 paralogues. Ubiquitous expression in spleen (RPKM 25.4), lymph node (RPKM 18.1) and 24 other tissues.

Summary

The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]

BTN3A1 Products (4)

mRNA Protein Name
NM_001145008.2 NP_001138480.1 butyrophilin subfamily 3 member A1 isoform c precursor
NM_001145009.2 NP_001138481.1 butyrophilin subfamily 3 member A1 isoform d precursor
NM_007048.6 NP_008979.3 butyrophilin subfamily 3 member A1 isoform a precursor
NM_194441.3 NP_919423.1 butyrophilin subfamily 3 member A1 isoform b precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21982860 GOA
Biological Process GO Annotation Evidence References Source
involved in T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
21918970 GOA
involved in activated T cell proliferation IMP
IMP: Inferred from mutant phenotype
21918970 GOA
involved in positive regulation of cytokine production IDA
IDA: Inferred from direct assay
21918970 GOA
involved in positive regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
21918970 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
21918970 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTN3A1 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (31 - 134)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (164 - 226)

PRY

PRY: SPRY-associated domain (342 - 390)

SPRY

SPRY: SPRY domain (392 - 498)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 513 a.a.
Protein Preferred Names Protein Names

butyrophilin subfamily 3 member A1

  • dJ45P21.3 (butyrophilin, subfamily 3, member A1)

BTN3A1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BTN3A1 O00481 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
BTN3A1 O00481 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
BTN3A1 O00481 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
BTN3A1 O00481 PPL Homo sapiens O60437
ITC
25637025
Intra
BTN3A1 O00481 PPL Homo sapiens O60437
Y2H
25637025
Intra
BTN3A1 O00481 PPL Homo sapiens O60437
Anti Tag CoIP
25637025
Intra
BTN3A1 O00481 PPL Homo sapiens O60437
Pull Down
25637025
Intra
BTN3A1 O00481 TFF1 Homo sapiens P04155
SPR
21982860
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BTN3A1 Proteins

Cat. No. Product Name Accession Purity
HY-P7683 BTN3A1/CD277 Protein, Human (HEK293, Fc) O00481-1 (Q30-G254) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72763 BTN3A1/CD277 Protein, Human (HEK293, His) O00481-1 (Q30-G254) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72345 BTN3A1/CD277 Protein, Human (Biotinylated, HEK293, Fc-Avi) O00481-1 (Q30-G254) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P76179 BTN3A1/CD277 Protein, Human (HEK293) O00481-1 (Q30-G254) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76182 BTN3A1/CD277 Protein, Human (Biotinylated, HEK293, His) O00481-1 (Q30-G254) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78080 BTN3A1/CD277 Protein, Human (Biotinylated, HEK293, His-Avi) O00481-1 (Q30-G254) ≥ 95%, as determined by Bis-Tris PAGE.

BTN3A1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81621 BTN3A1 Antibody (YA1366) FC, ELISA Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-134891 HMBPP lithium Inhibitor 98.0% Unkown
HY-RS01673 BTN3A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-170956 BTN3A1 ligand-1 / Unkown
HY-186052 4-M-HMBPP / Unkown

Orthologs Information

Species Symbol Source ID
Macaca fascicularis BTN3A1 NCBI