HHLA2 - HERV-H LTR-associating 2 Gene

Also Known as B7y; B7H7; B7-H5; B7-H7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11148

About HHLA2

Cytogenetic location: 3q13.13 Genomic coordinates (GRCh38): 3:108,296,548-108,378,285 (from NCBI)

This gene has 9 transcripts (splice variants), 101 orthologues and 15 paralogues. Biased expression in small intestine (RPKM 36.3), colon (RPKM 25.6) and 4 other tissues.

Summary

This gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

HHLA2 Products (6)

mRNA Protein Name
NM_001282556.2 NP_001269485.1 HERV-H LTR-associating protein 2 isoform a precursor
NM_001282557.2 NP_001269486.1 HERV-H LTR-associating protein 2 isoform a precursor
NM_001282558.2 NP_001269487.1 HERV-H LTR-associating protein 2 isoform b precursor
NM_001282559.2 NP_001269488.1 HERV-H LTR-associating protein 2 isoform c
NM_001370244.1 NP_001357173.1 HERV-H LTR-associating protein 2 isoform a precursor
NM_007072.4 NP_009003.1 HERV-H LTR-associating protein 2 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23784006 GOA
Biological Process GO Annotation Evidence References Source
involved in T cell costimulation IDA
IDA: Inferred from direct assay
23784006 GOA
involved in positive regulation of activated T cell proliferation IDA
IDA: Inferred from direct assay
23784006 GOA
involved in positive regulation of cytokine production IDA
IDA: Inferred from direct assay
23784006 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HHLA2 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (43 - 137)

C1-set

C1-set: Immunoglobulin C1-set domain (149 - 219)

V-set

V-set: Immunoglobulin V-set domain (233 - 331)

  • 0
  • 100
  • 200
  • 300
  • 414 a.a.
Protein Preferred Names Protein Names

HERV-H LTR-associating protein 2

  • human endogenous retrovirus-H long terminal repeat-associating protein 2

Recombinant HHLA2 Proteins

Cat. No. Product Name Accession Purity
HY-P76970 HHLA2 Protein, Human (HEK293, Fc) Q9UM44-1/NP_009003.1 (I23-N344) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P76971 HHLA2 Protein, Human (HEK293, His) Q9UM44-1/NP_009003.1 (I23-N344) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78927 HHLA2 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q9UM44-1 (I23-N344) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06162 HHLA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26184 Hhla2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992193 Anti-B7-H7 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus HHLA2 VGNC VGNC:29843
Rattus norvegicus HHLA2 RGD RGD:11472061
Macaca mulatta HHLA2 VGNC VGNC:73377
Others HHLA2 NCBI