CHRM4 - cholinergic receptor muscarinic 4 Gene
Also Known as HM4; M4R
Species: Homo sapiens
About CHRM4
This gene has 2 transcripts (splice variants), 187 orthologues and 25 paralogues.
Summary
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as Adenylate Cyclase inhibition, phosphoinositide degeneration, and Potassium Channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]
CHRM4 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_000741.5 | NP_000732.2 | muscarinic acetylcholine receptor M4 |
| NM_001366692.2 | NP_001353621.1 | muscarinic acetylcholine receptor M4 |
CHRM4 Protein Structure
7tm_1: 7 transmembrane receptor (rhodopsin family) (49 - 453)
- 0
- 100
- 200
- 300
- 400
- 479 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
muscarinic acetylcholine receptor M4 |
|
CHRM4 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P811189 | CHRM4 Antibody | WB, ICC/IF | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Cardiomyopathy, Familial Hypertrophic, 11 |
|
|
| Spherocytosis, Type 3 |
|
|
| Schizophrenia |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | CHRM4 | VGNC | VGNC:60876 |
| Mus musculus | CHRM4 | MGD | MGI:88399 |
| Bos taurus | CHRM4 | VGNC | VGNC:54862 |
| Rattus norvegicus | CHRM4 | RGD | RGD:2344 |
| Canis familiaris | CHRM4 | VGNC | VGNC:39234 |
| Macaca mulatta | CHRM4 | VGNC | VGNC:100913 |
| Others | CHRM4 | NCBI |