CHRM4 - cholinergic receptor muscarinic 4 Gene

Also Known as HM4; M4R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1132

About CHRM4

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:46,383,789-46,391,776 (from NCBI)

This gene has 2 transcripts (splice variants), 187 orthologues and 25 paralogues.

Summary

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as Adenylate Cyclase inhibition, phosphoinositide degeneration, and Potassium Channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]

CHRM4 Products (2)

mRNA Protein Name
NM_000741.5 NP_000732.2 muscarinic acetylcholine receptor M4
NM_001366692.2 NP_001353621.1 muscarinic acetylcholine receptor M4

CHRM4 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (49 - 453)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 479 a.a.
Protein Preferred Names Protein Names

muscarinic acetylcholine receptor M4

  • acetylcholine receptor, muscarinic 4

CHRM4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811189 CHRM4 Antibody WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Cardiomyopathy, Familial Hypertrophic, 11
  • Hypertrophic Cardiomyopathy 11

  • CMH11

  • Cardiomyopathy, Hypertrophic, 11

  • Cardiomyopathy Familial Hypertrophic 11

  • Cardiomyopathy, Familial Hypertrophic 11

  • Cardiomyopathy, Hypertrophic, Familial, Type 11

Spherocytosis, Type 3
  • Hereditary Spherocytosis Type 3

  • SPH3

  • Hs3

  • Spherocytosis, Hereditary, 3

  • Hereditary Spherocytosis 3

  • Spherocytosis 3

Schizophrenia
  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus CHRM4 VGNC VGNC:60876
Mus musculus CHRM4 MGD MGI:88399
Bos taurus CHRM4 VGNC VGNC:54862
Rattus norvegicus CHRM4 RGD RGD:2344
Canis familiaris CHRM4 VGNC VGNC:39234
Macaca mulatta CHRM4 VGNC VGNC:100913
Others CHRM4 NCBI