LACTB - lactamase beta Gene

Also Known as G24; MRPL56

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 114294

About LACTB

Cytogenetic location: 15q22.2 Genomic coordinates (GRCh38): 15:63,121,861-63,142,061 (from NCBI)

This gene has 4 transcripts (splice variants), 195 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 9.0), adrenal (RPKM 7.3) and 25 other tissues.

Summary

This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for Beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic function. Increased expression of the related mouse gene was found to be associated with obesity. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Dec 2013]

LACTB Products (3)

mRNA	Protein	Name
NM_001288585.2	NP_001275514.1	serine beta-lactamase-like protein LACTB, mitochondrial isoform c precursor
NM_032857.5	NP_116246.2	serine beta-lactamase-like protein LACTB, mitochondrial isoform a precursor
NM_171846.4	NP_741982.1	serine beta-lactamase-like protein LACTB, mitochondrial isoform b precursor

LACTB Protein Structure

Beta-lactamase

0
100
200
300
400
500
547 a.a.

Protein Preferred Names	Protein Names
serine beta-lactamase-like protein LACTB, mitochondrial	mitochondrial 39S ribosomal protein L56

LACTB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	LACTB	P83111	CCDC102A	Homo sapiens	Q96A19	Anti Tag CoIP	28514442
Intra	LACTB	P83111	CCDC102A	Homo sapiens	Q96A19	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Lung Abscess	Apical Lung Abscess Abscess Of Lung Abscess Of Lung Nos Pulmonary Abscess Multiple Abscess Of Lung
Gastroenteritis	Cholera Morbus Infectious Colitis, Enteritis And Gastroenteritis Enteritis Due To Astrovirus Rotaviral Gastroenteritis Viral Gastroenteritis Due To Rotavirus
Pharyngitis	Acute Pharyngitis Chronic Pharyngitis Acute Sore Throat Chronic Sore Throat Persistent Sore Throat Pharyngeal Diseases Chronic Pharyn/Nasopharyngitis Chronic Pharyngitis And Nasopharyngitis Inflamed Throat Pharyngeal Disease Pharyngeal Disorder Pharyngitis - Acute Sore Throat - Chronic Acute Pharyngitis Nos Acute Sore Throat Nos Acute Throat Inflammation Infective Pharyngitis Infection Of Pharynx Acute Infective Pharyngitis Acute Infective Pharyngitis Nos Acute Pharyngeal Inflammation Inflammation Of The Throat Throat Inflammation Throat Infection Putrid Pharyngitis Pharyngeal Inflammation Pharyngitis Nos Chronic Throat Pain Throat Catarrh
Haemophilus Influenzae
Mycobacterium Fortuitum
Tonsillitis	Chronic Tonsillitis Throat Infection - Tonsillitis
Aspiration Pneumonia	Pneumonia, Aspiration Pneumonia Aspiration Aspiration Pneumonitis
Epiglottitis	Acute Epiglottitis Acute Epiglottitis And Supraglottitis Acute Epiglottiditis Epiglottiditis Epiglottitis Nos
Klebsiella Pneumonia	Pneumonia Due To Klebsiella Pneumoniae Klebsiella Infections Doid:13272 Klebsiella Lobar Pneumonia
Bacteremia 2	Bacteremia Bacteremia, Susceptibility To, 2 BACTS2 Bacteremia, Susceptibility To Bacteremia, Susceptibility To, Type 2
Otitis Media	Opsoclonus-Myoclonus Syndrome OMS Otitis Media, Susceptibility To Kinsbourne Syndrome Otitis Media, Chronic/Recurrent Come/Rom Ataxo-Opso-Myoclonus Syndrome Dancing Eye Syndrome Dancing Eye-Dancing Feet Syndrome Oma Syndrome Opsoclonus Myoclonus Syndrome Opsoclonus-Myoclonus-Ataxia Syndrome Poma Syndrome Paraneoplastic Opsoclonus-Myoclonus Paraneoplastic Opsoclonus-Myoclonus-Ataxia Syndrome Opsoclonus Myoclonus OM {Otitis Media, Susceptibility To} Infectious Otitis Media
Mediastinitis
Bronchitis	Chronic Bronchitis Acute Bronchitis Bronchitis, Chronic Acute Bronchitis And Bronchiolitis Chest Cold Chest Infection Ci - Chest Infection Recurrent Wheezy Bronchitis Bronchitis Chronic Lower Respiratory Tract Infection Acute Lower Respiratory Tract Infection Chronic Bronchitis Nos Senile Bronchitis Bronchitis Nos In Those Under L5 Years Of Age Bronchitis Nos
Bacterial Pneumonia	Gram-Negative Pneumonia Pneumonia Due To Other Gram-Negative Bacteria Pneumonia Bacterial Pneumonia, Bacterial Acute Bacillus Pneumonia Acute Bacterial Pneumonia Bacillus Double Pneumonia Bacillus Pneumonia Bacteria Pneumonia Bacterial Double Pneumonia Bacterial Lobar Pneumonia Bacterial Purulent Pneumonia Bronchopneumonia Due To Bacteria Other Than S. Pneumoniae And H. Influenzae
Meningitis	Streptococcal Meningitis Acute Streptococcal Meningitis Staphylococcal Meningitis Adenoviral Meningitis Influenza Meningitis Influenzal Meningitis Meningitis Due To H. Influenzae Cryptococcal Meningitis Fungal Meningitis Due To Cryptococcus Neoformans Cryptococcosis Meningitis Cryptococcus Meningitis Cryptococcal Meningoencephalitis Meningitis Due To Cryptococcus Mumps Virus Meningitis Mumps Meningitis
Bacterial Meningitis	Meningitis, Bacterial Meningitis Bacterial Bm - [Bacterial Meningitis] Leptomeningitis Bacterial Pachymeningitis Bacterial Arachnoiditis Bacterial
Endocarditis
Pneumonia	Acute Pneumonia Pneumonias Infectious Pneumonia Pn - [Pneumonia] Lobar Pneumonia Nos Multifocal Pneumonia Orthostatic Pneumonia Pneumonia Nos Chronic Pneumonia Nos Atypical Pneumonia Passive Pneumonia Purulent Pneumonia Interstitial Lobar Pneumonia Pneumonia, Unspecified Pneumonia Due To Chlamydia Pneumonia Due To Chlamydia Pneumoniae Pneumonia Due To E. Coli Escherichia Coli Lobar Pneumonia Pneumonia Due To H. Influenzae Pneumonia Due To Hemophilus Influenzae Bronchopneumonia Due To H. Influenzae Haemophilus Influenzae Lobar Pneumonia Bronchopneumonia Due To Hemophilus Influenzae Pseudomonal Pneumonia Pseudomonas Pneumonia Pseudomonas Lobar Pneumonia Staphylococcal Pneumonia Staphylococcus Pneumonia Acute Staphylococcal Pneumonia Staphylococcal Double Pneumonia Staphylococcal Lobar Pneumonia Staphylococcal Purulent Pneumonia Staphylococcal Bronchopneumonia Pneumococcal Pneumonia Pneumococcus Pneumonia Bronchopneumonia Due To S. Pneumoniae Pneumococcal Lobar Pneumonia Streptococcal Pneumoniae Pneumonia Streptococcus Pneumoniae Lobar Pneumonia Pyemic Pneumococcal Embolism With Pneumonia Bronchopneumonia Due To Streptococcus Pneumoniae Pneumonia Due To Streptococcus, Group B Group B Streptococcal Pneumonia Adenovirus Pneumonia Adenoviral Pneumonia Adenovirus Viral Pneumonia Pneumonia Respiratory Syncytial Viral Parainfluenza Viral Pneumonia Parainfluenzal Pneumonia Parainfluenza Virus Pneumonia Human Metapneumovirus Pneumonia Human Metapneumovirus Infection Resulting In Pneumonia Pneumocystis Pneumonia Plasma Cells Pneumonia
Maxillary Sinusitis
Pelvic Inflammatory Disease	Pid
Intracranial Abscess	Abscess Of Brain Brain Empyema Cranial Abscess Intracerebral Abscess Cerebral Abscess Cerebral Embolic Abscess Cerebral Pyogenic Abscess Septic Brain Infection Temporosphenoidal Abscess Ventricular Empyema Intracranial Suppuration Intracranial Vein Sinus Abscess
Cellulitis
Endometritis
Beta-Lactam Allergy
Syphilis	Chancre Syphilitic Chancre
Mastitis	Breast Inflammation Inflammatory Breast Disease Inflammatory Disease Of Breast Inflammation Of Non-Human Mammary Gland Inflammatory Disorder Of Breast Mastitis Nos Acute Mastitis Nos Acute Nonpuerperal Mastitis Nonpuerperal Mastitis Nos Subacute Mastitis Nos
Disease By Infectious Agent	Infectious Disease Infectious Diseases
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Meningococcal Infection	Meningococcal Disease Meningococcal Infections Neisseria Meningitidis Infection Meningococcal Diseases Meningococcus Infection Due To Neisseria Meningitidis Meningococcal Disease Nos Meningococcal Infection Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-178018	D574-0246		99.95%	Unkown
HY-RS07489	LACTB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07490	LACTB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20049	Lactb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20172	Lactb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26553	Lactb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26676	Lactb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LACTB	RGD	RGD:1304788
Macaca mulatta	LACTB	VGNC	VGNC:74059
Bos taurus	LACTB	VGNC	VGNC:30764
Canis familiaris	LACTB	VGNC	VGNC:42559
Felis catus	LACTB	VGNC	VGNC:63185
Mus musculus	LACTB	MGD	MGI:1933395
Others	LACTB	NCBI