ERMAP - erythroblast membrane associated protein (Scianna blood group) Gene

Also Known as RD; SC; BTN5; PRO2801

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 114625

About ERMAP

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:42,817,122-42,844,991 (from NCBI)

This gene has 9 transcripts (splice variants), 99 orthologues, 15 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 13.2), thyroid (RPKM 8.4) and 25 other tissues.

Summary

The protein encoded by this gene is a cell surface transmembrane protein that may act as an erythroid cell receptor, possibly as a mediator of cell adhesion. Polymorphisms in this gene are responsible for the Scianna/Radin blood group system. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

ERMAP Products (2)

mRNA Protein Name
NM_001017922.2 NP_001017922.1 erythroid membrane-associated protein precursor
NM_018538.4 NP_061008.2 erythroid membrane-associated protein precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
11549310 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERMAP Protein Structure

V-set

V-set: Immunoglobulin V-set domain (40 - 133)

PRY

PRY: SPRY-associated domain (240 - 288)

SPRY

SPRY: SPRY domain (291 - 395)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 475 a.a.
Protein Preferred Names Protein Names

erythroid membrane-associated protein

  • Radin blood group (Rd)

ERMAP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ERMAP Q96PL5 TMEM14A Homo sapiens Q9Y6G1
Validated Y2H
32296183
Intra
ERMAP Q96PL5 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Intra
ERMAP Q96PL5 KRTAP3-3 Homo sapiens Q9BYR6
Validated Y2H
32296183
Intra
ERMAP Q96PL5 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ERMAP Proteins

Cat. No. Product Name Accession Purity
HY-P70896 ERMAP Protein, Human (HEK293, His) Q96PL5 (H30-A155) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Radin Blood Group Antigen

  • RD

  • Blood Group--Radin Antigen
Scarlet Fever

  • Scarlatina

  • Scarlatina Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04503 ERMAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18663 Ermap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25149 Ermap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ERMAP VGNC VGNC:99910
Felis catus ERMAP VGNC VGNC:80201
Mus musculus ERMAP MGD MGI:1349816
Rattus norvegicus ERMAP RGD RGD:1309996
Others ERMAP NCBI