2. Gene
  3. Acvr1 - activin A receptor, type 1 Gene

Acvr1 - activin A receptor, type 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ALK2; Acvr; Alk8; SKR1; Alk-2; Tsk7L; ActR-I; ActRIA; Acvr1a; Acvrlk2; D330013D15Rik

Gene ID: 11477 | Gene type: protein coding

About Acvr1

Chromosome 2: 58,278,656-58,457,169 reverse strand.GRCm39:CM000995.3

This gene has 6 transcripts (splice variants), 174 orthologues, 11 paralogues and is associated with 43 phenotypes. Ubiquitous expression in bladder adult (RPKM 6.5), limb E14.5 (RPKM 6.5) and 28 other tissues.

Summary

Enables activin binding activity; transforming growth factor beta binding activity; and transmembrane receptor protein serine/threonine kinase activity. Involved in heart development; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within several processes, including chordate embryonic development; circulatory system development; and gastrulation. Located in apical part of cell. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; limb; male reproductive gland or organ; and sensory organ. Used to study fibrodysplasia ossificans progressiva. Human ortholog(s) of this gene implicated in fibrodysplasia ossificans progressiva. Orthologous to human ACVR1 (Activin A receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

Acvr1 Products(5)

mRNA Protein Name
NM_001355049.1 NP_001341978.1 activin receptor type-1 precursor
NM_007394.3 NP_031420.2 activin receptor type-1 precursor
NM_001355048.1 NP_001341977.1 activin receptor type-1 precursor
NM_001110204.1 NP_001103674.1 activin receptor type-1 precursor
NM_001110205.1 NP_001103675.1 activin receptor type-1 precursor

Acvr1 Protein Structure

Activin_recp

Activin_recp: pfam01064 (32 - 102)

TGF_beta_GS

TGF_beta_GS: pfam08515 (178 - 205)

STKc_ACVR1_ALK1

STKc_ACVR1_ALK1: cd14142 (201 - 498)

  • 0
  • 100
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  • 400
  • 509 a.a.
Protein Preferred Names Protein Names

activin receptor type-1

TGF-B superfamily receptor type I

TSK-7L

TSR-I

activin receptor type I

serine/threonine-protein kinase receptor R1

Recombinant Acvr1 Proteins

Cat. No. Product Name Accession Purity
HY-P75539 ACVR1 Protein, Mouse (HEK293, His-hFc) P37172 (M1-E123) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-109179 Itacnosertib Inhibitor 99.77% Phase 2
Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109179A Itacnosertib (hydrocholide) Inhibitor 98.98% Unkown
HY-RS00236 ACVR1 Human Pre-designed siRNA Set A / Unkown
HY-RS00237 Acvr1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS00238 Acvr1 Rat Pre-designed siRNA Set A / Unkown
HY-RS00239 ACVR1B Human Pre-designed siRNA Set A / Unkown
HY-RS00240 Acvr1b Mouse Pre-designed siRNA Set A / Unkown
HY-RS00241 Acvr1b Rat Pre-designed siRNA Set A / Unkown
HY-RS00242 ACVR1C Human Pre-designed siRNA Set A / Unkown
HY-RS00243 Acvr1c Mouse Pre-designed siRNA Set A / Unkown
HY-RS00244 Acvr1c Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acvr1 NCBI NCBI:90
Canis familiaris Acvr1 NCBI NCBI:478757
Macaca fascicularis Acvr1 NCBI NCBI:102134051
Rattus norvegicus Acvr1 NCBI NCBI:79558
Macaca mulatta Acvr1 NCBI NCBI:697935