2. Gene
  3. Acvr1b - activin A receptor, type 1B Gene

Acvr1b - activin A receptor, type 1B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Alk4; SKR2; ALK-4; ActRIB; ActR-IB; Acvrlk4; 6820432J04

Gene ID: 11479 | Gene type: protein coding

About Acvr1b

Chromosome 15: 101,071,948-101,111,565 forward strand.GRCm39:CM001008.3

This gene has 1 transcript (splice variant), 271 orthologues, 11 paralogues and is associated with 27 phenotypes. Ubiquitous expression in colon adult (RPKM 35.), lung adult (RPKM 24.6) and 28 other tissues.

Summary

Enables activin binding activity and protein serine/threonine kinase activity. Involved in peptidyl-threonine phosphorylation. Acts upstream of or within several processes, including activin receptor signaling pathway; hair follicle development; and regulation of gene expression. Predicted to be located in cell surface and cytosol. Predicted to be integral component of plasma membrane. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human ACVR1B (Activin A receptor type 1B). [provided by Alliance of Genome Resources, Apr 2022]

Acvr1b Products(1)

mRNA Protein Name
NM_007395.4 NP_031421.1 activin receptor type-1B precursor

Acvr1b Protein Structure

Activin_recp

Activin_recp: pfam01064 (31 - 103)

GS

GS: smart00467 (176 - 206)

STKc_TGFbR1_ACVR1b_ACVR1c

STKc_TGFbR1_ACVR1b_ACVR1c: cd14143 (210 - 497)

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  • 505 a.a.
Protein Preferred Names Protein Names

activin receptor type-1B

activin receptor type IB

activin receptor-like kinase 4

serine/threonine-protein kinase receptor R2

Recombinant Acvr1b Proteins

Cat. No. Product Name Accession Purity
HY-P7486 Activin RIB/ALK-4 Protein, Mouse (HEK293, Fc) Q61271 (L32-E126) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00239 ACVR1B Human Pre-designed siRNA Set A / Unkown
HY-RS00240 Acvr1b Mouse Pre-designed siRNA Set A / Unkown
HY-RS00241 Acvr1b Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acvr1b NCBI NCBI:91
Rattus norvegicus Acvr1b NCBI NCBI:29381
Macaca mulatta Acvr1b NCBI NCBI:696587