Acvr1b - activin A receptor, type 1B Gene

Also Known as Alk4; SKR2; ALK-4; ActRIB; ActR-IB; Acvrlk4; 6820432J04

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11479

About Acvr1b

Chromosome 15: 101,071,948-101,111,565 forward strand.GRCm39:CM001008.3

This gene has 1 transcript (splice variant), 271 orthologues, 11 paralogues and is associated with 27 phenotypes. Ubiquitous expression in colon adult (RPKM 35.), lung adult (RPKM 24.6) and 28 other tissues.

Summary

Enables activin binding activity and protein serine/threonine kinase activity. Involved in peptidyl-threonine phosphorylation. Acts upstream of or within several processes, including activin receptor signaling pathway; hair follicle development; and regulation of gene expression. Predicted to be located in cell surface and cytosol. Predicted to be integral component of plasma membrane. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human ACVR1B (Activin A receptor type 1B). [provided by Alliance of Genome Resources, Apr 2022]

Acvr1b Products (1)

mRNA Protein Name
NM_007395.4 NP_031421.1 activin receptor type-1B precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables activin binding IPI
IPI: Inferred from physical interaction
7577669 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18039968 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
18039968 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within activin receptor signaling pathway IDA
IDA: Inferred from direct assay
16115198 MGI
acts upstream of or within embryo development IMP
IMP: Inferred from mutant phenotype
9512518 MGI
acts upstream of or within hair follicle development IMP
IMP: Inferred from mutant phenotype
16127153 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
15485907 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23152446 MGI
involved in peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
18039968 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23152446 MGI
acts upstream of or within regulation of signal transduction IDA
IDA: Inferred from direct assay
17936261 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Acvr1b Protein Structure

Activin_recp

Activin_recp: pfam01064 (31 - 103)

GS

GS: smart00467 (176 - 206)

STKc_TGFbR1_ACVR1b_ACVR1c

STKc_TGFbR1_ACVR1b_ACVR1c: cd14143 (210 - 497)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
Protein Preferred Names Protein Names

activin receptor type-1B

  • activin receptor type IB

  • activin receptor-like kinase 4

  • serine/threonine-protein kinase receptor R2

Recombinant Acvr1b Proteins

Cat. No. Product Name Accession Purity
HY-P7486 Activin RIB/ALK-4 Protein, Mouse (HEK293, Fc) Q61271/NP_031421.1 (L32-E126) ≥ 80%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00239 ACVR1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00240 Acvr1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00241 Acvr1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174785 Human ACVR1B mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acvr1b NCBI NCBI:91