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PWWP2A - PWWP domain containing 2A Gene

Also Known as MST101

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 114825

About PWWP2A

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:160,044,316-160,119,450 (from NCBI)

This gene has 6 transcripts (splice variants), 210 orthologues, 4 paralogues and is associated with 57 phenotypes. Ubiquitous expression in colon (RPKM 1.9), skin (RPKM 1.8) and 25 other tissues.

Summary

Enables chromatin binding activity and histone binding activity. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PWWP2A Products (7)

mRNA	Protein	Name
NM_001130864.2	NP_001124336.1	PWWP domain-containing protein 2A isoform b
NM_001267035.3	NP_001253964.1	PWWP domain-containing protein 2A isoform c
NM_001349732.2	NP_001336661.1	PWWP domain-containing protein 2A isoform d
NM_001349733.2	NP_001336662.1	PWWP domain-containing protein 2A isoform e
NM_001349734.2	NP_001336663.1	PWWP domain-containing protein 2A isoform f
NM_001349735.2	NP_001336664.1	PWWP domain-containing protein 2A isoform f
NM_052927.4	NP_443159.1	PWWP domain-containing protein 2A isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables NuRD complex binding	IDA IDA: Inferred from direct assay	30228260	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	28645917	GOA
enables histone binding	IPI IPI: Inferred from physical interaction	28645917	GOA
enables methylated histone binding	IDA IDA: Inferred from direct assay	30228260	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23752268	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chromatin remodeling	IMP IMP: Inferred from mutant phenotype	30327463	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	28645917	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PWWP2A Protein Structure

PWWP

0
200
400
600
755 a.a.

Protein Preferred Names	Protein Names
PWWP domain-containing protein 2A	MSTP101

PWWP2A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PWWP2A	Q96N64	H2BC21	Homo sapiens	Q16778	Crosslink	30021884
Intra	PWWP2A	Q96N64	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	23752268

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spitzoid Melanoma	Atypical Spitz Nevus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11477	PWWP2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PWWP2A	VGNC	VGNC:76564
Felis catus	PWWP2A	VGNC	VGNC:102299
Mus musculus	PWWP2A	MGD	MGI:1918052
Rattus norvegicus	PWWP2A	RGD	RGD:1305891
Bos taurus	PWWP2A	VGNC	VGNC:55301
Others	PWWP2A	NCBI