Ada - adenosine deaminase Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11486

About Ada

Chromosome 2: 163,568,504-163,592,159 reverse strand.GRCm39:CM000995.3

This gene has 2 transcripts (splice variants), 218 orthologues, 1 paralogue and is associated with 40 phenotypes. Biased expression in small intestine adult (RPKM 276.4), placenta adult (RPKM 134.5) and 4 other tissues.

Summary

Enables 2'-deoxyadenosine deaminase activity; Adenosine Deaminase activity; and zinc ion binding activity. Involved in allantoin metabolic process and purine nucleoside monophosphate metabolic process. Acts upstream of or within several processes, including animal organ development; nucleobase-containing small molecule metabolic process; and positive regulation of lymphocyte activation. Located in cytoplasm. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and sensory organ. Used to study Adenosine Deaminase deficiency. Human ortholog(s) of this gene implicated in Adenosine Deaminase deficiency; asthma; and severe combined immunodeficiency. Orthologous to human ADA (Adenosine Deaminase). [provided by Alliance of Genome Resources, Apr 2022]

Ada Products (2)

mRNA Protein Name
NM_007398.4 NP_031424.1 adenosine deaminase
NM_001272052.1 NP_001258981.1 adenosine deaminase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 2'-deoxyadenosine deaminase activity IMP
IMP: Inferred from mutant phenotype
10720488 MGI
enables adenosine deaminase activity IDA
IDA: Inferred from direct assay
718989 MGI
enables adenosine deaminase activity IMP
IMP: Inferred from mutant phenotype
7731963 MGI
enables zinc ion binding IDA
IDA: Inferred from direct assay
8672487 MGI
enables zinc ion binding IMP
IMP: Inferred from mutant phenotype
8634299 MGI
Biological Process GO Annotation Evidence References Source
involved in AMP catabolic process IDA
IDA: Inferred from direct assay
8064675 MGI
involved in AMP salvage IDA
IDA: Inferred from direct assay
8064675 MGI
acts upstream of B cell proliferation IMP
IMP: Inferred from mutant phenotype
14607964 MGI
involved in GMP salvage IDA
IDA: Inferred from direct assay
718989 MGI
acts upstream of or within Peyer's patch development IMP
IMP: Inferred from mutant phenotype
10720488 MGI
acts upstream of T cell activation IMP
IMP: Inferred from mutant phenotype
10845921 MGI
acts upstream of T cell differentiation IMP
IMP: Inferred from mutant phenotype
7731963 MGI
acts upstream of T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
11067867 MGI
acts upstream of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11435465 MGI
acts upstream of or within adenosine catabolic process IDA
IDA: Inferred from direct assay
1618849 MGI
involved in adenosine catabolic process IDA
IDA: Inferred from direct assay
8064675 MGI
acts upstream of or within adenosine catabolic process IMP
IMP: Inferred from mutant phenotype
7670465 MGI
involved in allantoin metabolic process IDA
IDA: Inferred from direct assay
8064675 MGI
involved in allantoin metabolic process IMP
IMP: Inferred from mutant phenotype
10720488 MGI
acts upstream of alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
11067867 MGI
involved in amide catabolic process IDA
IDA: Inferred from direct assay
8064675 MGI
involved in amide catabolic process IMP
IMP: Inferred from mutant phenotype
10720488 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
7670465 MGI
acts upstream of calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
11435465 MGI
involved in dAMP catabolic process IMP
IMP: Inferred from mutant phenotype
10720488 MGI
acts upstream of or within dATP catabolic process IDA
IDA: Inferred from direct assay
7592575 MGI
acts upstream of or within dATP catabolic process IMP
IMP: Inferred from mutant phenotype
7670465 MGI
acts upstream of or within deoxyadenosine catabolic process IDA
IDA: Inferred from direct assay
7592575 MGI
acts upstream of or within deoxyadenosine catabolic process IMP
IMP: Inferred from mutant phenotype
7670465 MGI
involved in deoxyadenosine catabolic process IMP
IMP: Inferred from mutant phenotype
10720488 MGI
acts upstream of or within embryonic digestive tract development IMP
IMP: Inferred from mutant phenotype
7670465 MGI
acts upstream of or within germinal center B cell differentiation IMP
IMP: Inferred from mutant phenotype
14607964 MGI
acts upstream of germinal center formation IMP
IMP: Inferred from mutant phenotype
14607964 MGI
acts upstream of or within hypoxanthine biosynthetic process IMP
IMP: Inferred from mutant phenotype
10720488 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
7731963 MGI
acts upstream of or within inosine biosynthetic process IDA
IDA: Inferred from direct assay
1618849 MGI
involved in inosine biosynthetic process IDA
IDA: Inferred from direct assay
8672487 MGI
acts upstream of or within inosine biosynthetic process IMP
IMP: Inferred from mutant phenotype
7731963 MGI
acts upstream of leukocyte migration IGI
IGI: Inferred from genetic interaction
15240734 MGI
acts upstream of leukocyte migration IMP
IMP: Inferred from mutant phenotype
15240734 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
7670465 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
10899903 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
7670465 MGI
acts upstream of mature B cell apoptotic process IMP
IMP: Inferred from mutant phenotype
14607964 MGI
acts upstream of mucus secretion IGI
IGI: Inferred from genetic interaction
15240734 MGI
acts upstream of mucus secretion IMP
IMP: Inferred from mutant phenotype
15240734 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
7670465 MGI
acts upstream of or within negative regulation of inflammatory response IGI
IGI: Inferred from genetic interaction
15240734 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
10899903 MGI
acts upstream of or within negative regulation of leukocyte migration IGI
IGI: Inferred from genetic interaction
15240734 MGI
acts upstream of or within negative regulation of leukocyte migration IMP
IMP: Inferred from mutant phenotype
15240734 MGI
acts upstream of or within negative regulation of mature B cell apoptotic process IMP
IMP: Inferred from mutant phenotype
14607964 MGI
acts upstream of or within negative regulation of mucus secretion IGI
IGI: Inferred from genetic interaction
15240734 MGI
acts upstream of or within negative regulation of mucus secretion IMP
IMP: Inferred from mutant phenotype
15240734 MGI
acts upstream of or within negative regulation of penile erection IMP
IMP: Inferred from mutant phenotype
18340377 MGI
acts upstream of or within negative regulation of thymocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
11067867 MGI
acts upstream of penile erection IMP
IMP: Inferred from mutant phenotype
18340377 MGI
acts upstream of or within placenta development IMP
IMP: Inferred from mutant phenotype
9272950 MGI
acts upstream of or within positive regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
14607964 MGI
acts upstream of or within positive regulation of T cell activation IMP
IMP: Inferred from mutant phenotype
10845921 MGI
acts upstream of or within positive regulation of T cell differentiation IMP
IMP: Inferred from mutant phenotype
7731963 MGI
acts upstream of or within positive regulation of T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
11067867 MGI
acts upstream of or within positive regulation of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11435465 MGI
acts upstream of or within positive regulation of alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
11067867 MGI
acts upstream of or within positive regulation of calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
11435465 MGI
acts upstream of or within positive regulation of germinal center formation IMP
IMP: Inferred from mutant phenotype
14607964 MGI
acts upstream of or within positive regulation of heart rate IMP
IMP: Inferred from mutant phenotype
16626672 MGI
acts upstream of or within positive regulation of smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
18340377 MGI
acts upstream of or within regulation of T cell differentiation IMP
IMP: Inferred from mutant phenotype
7670465 MGI
acts upstream of smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
18340377 MGI
acts upstream of thymocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
11067867 MGI
acts upstream of or within trophectodermal cell differentiation IMP
IMP: Inferred from mutant phenotype
9272950 MGI
acts upstream of or within xanthine biosynthetic process IMP
IMP: Inferred from mutant phenotype
10720488 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
7691243 MGI
is active in cytosol IDA
IDA: Inferred from direct assay
16742956 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ada Protein Structure

A_deaminase

A_deaminase: pfam00962 (9 - 335)

  • 0
  • 100
  • 200
  • 300
  • 352 a.a.
Protein Preferred Names Protein Names

adenosine deaminase

  • adenosine aminohydrolase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-17377 Vicriviroc maleate 99.91% Phase 3
HY-137294 BTPTT-4F 98.0% Phase 3
HY-105017 Evodenoson Agonist 99.94% Phase 2
HY-19130 BW-534U87 Agonist / Phase 2

Pre-clinical Phase

Bioactive Molecules (25)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103160A EHNA hydrochloride Inhibitor 99.67% Unkown
HY-158009 SGF29-IN-1 Inhibitor 98.0% Unkown
HY-W011552 2'-O-Methyladenosine 99.76% Unkown
HY-N7368 Hibifolin Inhibitor 99.70% Unkown
HY-103237 L-Adenosine Inhibitor 99.82% Unkown
HY-D0855A ADA disodium 98.0% Unkown
HY-103159 1-Deazaadenosine Inhibitor 98.9% Unkown
HY-114175A Adenosine deaminase, Calf Spleen / Unkown
HY-D0855 ADA 98.53% Unkown
HY-W753672 2'-O-Methyladenosine-d3 97.54% Unkown
HY-181065 LS-170 Inhibitor / Unkown
HY-117260 Coformycin Inhibitor / Unkown
HY-103160B EHNA Inhibitor / Unkown
HY-P11846 ADA2 Ligand / Unkown
HY-P5201S VTSEGAGLQLQK-13C6,15N2 / Unkown
HY-RS00258 ADA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00259 Ada Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00260 Ada Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00261 ADA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W011552S 2'-O-Methyladenosine-d / Unkown
HY-W011552S1 2'-O-Methyladenosine-d2 / Unkown
HY-W011552S2 2'-O-Methyladenosine-d-1 / Unkown
HY-W129499 ADA sodium / Unkown
HY-133216 Bupirimate Inhibitor 99.77% Unkown
HY-180366 5-Amino-2'-deoxyuridine / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991440 AMG-966 Inhibitor 96.19% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ada NCBI NCBI:100