ARL11 - ADP ribosylation factor like GTPase 11 Gene

Also Known as ARLTS1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 115761

About ARL11

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:49,628,507-49,633,872 (from NCBI)

This gene has 2 transcripts (splice variants), 93 orthologues, 30 paralogues and is associated with 1 phenotype. Broad expression in lymph node (RPKM 2.7), spleen (RPKM 2.1) and 17 other tissues.

Summary

This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in Apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. [provided by RefSeq, May 2010]

ARL11 Products (1)

mRNA Protein Name
NM_138450.6 NP_612459.1 ADP-ribosylation factor-like protein 11

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARL11 Protein Structure

Arf

Arf: ADP-ribosylation factor family (8 - 170)

  • 0
  • 100
  • 196 a.a.
Protein Preferred Names Protein Names

ADP-ribosylation factor-like protein 11

  • ADP-ribosylation factor-like 11

ARL11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARL11 Q969Q4 TRIP13 Homo sapiens Q15645
Y2H Array
19060904
Intra
ARL11 Q969Q4 TRIP13 Homo sapiens Q15645
Y2H Pooling
19060904
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Leukemia, Chronic Lymphocytic

  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell
Chronic Leukemia

  • Adult Chronic Leukemia

  • Cll

  • Cml
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00979 ARL11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ARL11 VGNC VGNC:26137
Rattus norvegicus ARL11 RGD RGD:1308083
Macaca mulatta ARL11 VGNC VGNC:69889
Mus musculus ARL11 MGD MGI:2444054
Others ARL11 NCBI