Txnip - thioredoxin interacting protein Gene

Also Known as Vdup1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117514

Summary

Predicted to enable enzyme inhibitor activity and ubiquitin protein Ligase binding activity. Involved in several processes, including response to estradiol; response to glucose; and response to progesterone. Located in mitochondrial intermembrane space and nucleus. Used to study renal cell carcinoma. Biomarker of colorectal cancer; glaucoma; and stomach Cancer. Orthologous to human TXNIP (thioredoxin interacting protein). [provided by Alliance of Genome Resources, Apr 2022]

Txnip Products (1)

mRNA Protein Name
NM_001008767.2 NP_001008767.1 thioredoxin-interacting protein

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16172122 RGD
involved in regulation of cell population proliferation IDA
IDA: Inferred from direct assay
12011048 RGD
involved in response to calcium ion IEP
IEP: Inferred from expression pattern
11579135 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
15047938 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
12213820 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
12011048 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
12011048 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
15047938 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16782054 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thioredoxin-interacting protein

  • upregulated by 1,25-dihydroxyvitamin D-3

  • vitamin D3 up-regulated protein 1

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0004 Doxofylline 99.97% Yes

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19330 DASA-58 Activator 99.57% Unkown
HY-141623 SRI-37330 hydrochloride Inhibitor 99.72% Unkown
HY-142114 SRI-37330 Inhibitor 99.16% Unkown
HY-113328 Aminoadipic acid 99.94% Unkown
HY-N0496 Ruscogenin Inhibitor 99.85% Unkown
HY-122682 SBI-993 98.79% Unkown
HY-115688 TXNIP-IN-1 Inhibitor 99.19% Unkown
HY-124418 SBI-477 Inhibitor 98.0% Unkown
HY-155248 HL23 99.64% Unkown
HY-115688A (S)-TXNIP-IN-1 Control 99.73% Unkown
HY-RS16561 Txnip Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15295 TXNIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-Z15823 (R)-Verapamil 98.97% Unkown
HY-123996 3-Ethoxy-5,6-dibromosalicylaldehyde / Unkown
HY-149216 Anticancer agent 103 / Unkown
HY-169298 Ferroptosis-IN-15 Inhibitor / Unkown
HY-181335 SKL1223 Inhibitor / Unkown
HY-RS22993 Txnip Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Txnip NCBI NCBI:10628