2. Gene
  3. Birc3 - baculoviral IAP repeat-containing 3 Gene

Birc3 - baculoviral IAP repeat-containing 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Api1; Api2; IAP1; IAP2; MIHB; MIHC; Birc2; HIAP2; MIAP1; MIAP2; RNF49; cIAP1; cIAP2; C-IAP2; cIAP-1; cIAP-2

Gene ID: 11796 | Gene type: protein coding

About Birc3

Chromosome 9: 7,848,700-7,873,187 reverse strand.GRCm39:CM001002.3

This gene has 7 transcripts (splice variants), 205 orthologues, 10 paralogues and is associated with 27 phenotypes. Broad expression in spleen adult (RPKM 15.4), large intestine adult (RPKM 9.) and 2 other tissues.

Summary

Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Involved in several processes, including necroptotic process; negative regulation of necroptotic process; and negative regulation of Reactive Oxygen Species metabolic process. Acts upstream of or within cellular response to tumor necrosis factor; positive regulation of protein polyubiquitination; and regulation of NIK/NF-kappaB signaling. Predicted to be located in cytosol; membrane raft; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in genitourinary system. Orthologous to human BIRC3 (baculoviral IAP repeat containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Birc3 Products(1)

mRNA Protein Name
NM_007464.3 NP_031490.2 baculoviral IAP repeat-containing protein 3

Birc3 Protein Structure

BIR

BIR: smart00238 (27 - 96)

BIR

BIR: smart00238 (167 - 235)

BIR

BIR: smart00238 (253 - 323)

UBA_BIRC2_3

UBA_BIRC2_3: cd14394 (375 - 424)

CARD_BIRC2_BIRC3

CARD_BIRC2_BIRC3: cd08329 (439 - 527)

RING-HC_BIRC2_3_7

RING-HC_BIRC2_3_7: cd16713 (545 - 601)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 602 a.a.
Protein Preferred Names Protein Names

baculoviral IAP repeat-containing protein 3

IAP-1

RING-type E3 ubiquitin transferase BIRC3

apoptosis inhibitor 1

baculoviral IAP repeat-containing 2

cellular inhibitor of apoptosis 2

inhibitor of apoptosis protein 1

mIAP-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50685 A 410099.1 / Unkown
HY-RS01510 BIRC3 Human Pre-designed siRNA Set A / Unkown
HY-RS01511 Birc3 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01512 Birc3 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Birc3 NCBI NCBI:330