Birc3 - baculoviral IAP repeat-containing 3 Gene

Also Known as Api1; Api2; IAP1; IAP2; MIHB; MIHC; Birc2; HIAP2; MIAP1; MIAP2; RNF49; cIAP1; cIAP2; C-IAP2; cIAP-1; cIAP-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11796

About Birc3

Chromosome 9: 7,848,700-7,873,187 reverse strand.GRCm39:CM001002.3

This gene has 7 transcripts (splice variants), 205 orthologues, 10 paralogues and is associated with 27 phenotypes. Broad expression in spleen adult (RPKM 15.4), large intestine adult (RPKM 9.) and 2 other tissues.

Summary

Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein Ligase activity. Involved in several processes, including necroptotic process; negative regulation of necroptotic process; and negative regulation of Reactive Oxygen Species metabolic process. Acts upstream of or within cellular response to tumor necrosis factor; positive regulation of protein polyubiquitination; and regulation of NIK/NF-kappaB signaling. Predicted to be located in cytosol; membrane raft; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in genitourinary system. Orthologous to human BIRC3 (baculoviral IAP repeat containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Birc3 Products (1)

mRNA Protein Name
NM_007464.3 NP_031490.2 baculoviral IAP repeat-containing protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to tumor necrosis factor IGI
IGI: Inferred from genetic interaction
18621737 MGI
involved in necroptotic process IDA
IDA: Inferred from direct assay
21052097 MGI
involved in negative regulation of necroptotic process IMP
IMP: Inferred from mutant phenotype
21052097 MGI
involved in negative regulation of phosphorylation IMP
IMP: Inferred from mutant phenotype
21052097 MGI
involved in negative regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
21052097 MGI
acts upstream of or within positive regulation of protein polyubiquitination IGI
IGI: Inferred from genetic interaction
18621737 MGI
acts upstream of or within regulation of non-canonical NF-kappaB signal transduction IGI
IGI: Inferred from genetic interaction
18621737 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Birc3 Protein Structure

BIR

BIR: smart00238 (27 - 96)

BIR

BIR: smart00238 (167 - 235)

BIR

BIR: smart00238 (253 - 323)

UBA_BIRC2_3

UBA_BIRC2_3: cd14394 (375 - 424)

CARD_BIRC2_BIRC3

CARD_BIRC2_BIRC3: cd08329 (439 - 527)

RING-HC_BIRC2_3_7

RING-HC_BIRC2_3_7: cd16713 (545 - 601)

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  • 500
  • 602 a.a.
Protein Preferred Names Protein Names

baculoviral IAP repeat-containing protein 3

  • IAP-1

  • RING-type E3 ubiquitin transferase BIRC3

  • apoptosis inhibitor 1

  • baculoviral IAP repeat-containing 2

  • cellular inhibitor of apoptosis 2

  • inhibitor of apoptosis protein 1

  • mIAP-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-50685 A 410099.1 Inhibitor 99.30% Unkown
HY-180948 PZ-11 Inducer / Unkown
HY-182002 Apoptosis inducer 61 / Unkown
HY-RS01508 Birc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01510 BIRC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01511 Birc3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01512 Birc3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Birc3 NCBI NCBI:330