Birc2 - baculoviral IAP repeat-containing 2 Gene

Also Known as Api1; Api2; IAP1; IAP2; MIHB; MIHC; Birc3; HIAP1; HIAP2; MIAP1; MIAP2; RNF48; cIAP1; cIAP2; C-IAP1; mcIAP1; C330006D17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11797

About Birc2

Chromosome 9: 7,818,228-7,837,065 reverse strand.GRCm39:CM001002.3

This gene has 5 transcripts (splice variants), 218 orthologues, 10 paralogues and is associated with 3 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 9.), CNS E14 (RPKM 8.3) and 26 other tissues.

Summary

Predicted to enable several functions, including FBXO family protein binding activity; chaperone binding activity; and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in necroptotic process. Acts upstream of or within several processes, including cellular response to tumor necrosis factor; negative regulation of necroptotic process; and negative regulation of ripoptosome assembly involved in necroptotic process. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in brain ventricular layer; genitourinary system; and thymus primordium. Human ortholog(s) of this gene implicated in breast Cancer. Orthologous to human BIRC2 (baculoviral IAP repeat containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Birc2 Products (2)

mRNA Protein Name
NM_007465.3 NP_031491.2 baculoviral IAP repeat-containing protein 2
NM_001291503.1 NP_001278432.1 baculoviral IAP repeat-containing protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
11906213 MGI
enables ubiquitin-protein transferase activity IGI
IGI: Inferred from genetic interaction
19815541 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within cellular response to tumor necrosis factor IGI
IGI: Inferred from genetic interaction
18621737 MGI
involved in necroptotic process IMP
IMP: Inferred from mutant phenotype
21052097 MGI
acts upstream of or within negative regulation of necroptotic process IGI
IGI: Inferred from genetic interaction
21052097 MGI
acts upstream of or within negative regulation of ripoptosome assembly involved in necroptotic process IGI
IGI: Inferred from genetic interaction
21052097 MGI
acts upstream of or within placenta development IMP
IMP: Inferred from mutant phenotype
15640352 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IGI
IGI: Inferred from genetic interaction
19815541 MGI
acts upstream of or within positive regulation of protein polyubiquitination IGI
IGI: Inferred from genetic interaction
18621737 MGI
acts upstream of or within regulation of non-canonical NF-kappaB signal transduction IGI
IGI: Inferred from genetic interaction
18621737 MGI
acts upstream of or within regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
21052097 MGI
Cellular Component GO Annotation Evidence Verweise Source
part of CD40 receptor complex IDA
IDA: Inferred from direct assay
20614026 MGI
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
20614026 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Birc2 Protein Structure

BIR

BIR: smart00238 (44 - 113)

BIR

BIR: smart00238 (175 - 244)

BIR

BIR: cd00022 (262 - 328)

UBA_BIRC2_3

UBA_BIRC2_3: cd14394 (384 - 430)

CARD_BIRC2_BIRC3

CARD_BIRC2_BIRC3: cd08329 (446 - 537)

RING-HC_BIRC2_3_7

RING-HC_BIRC2_3_7: cd16713 (555 - 611)

  • 0
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  • 200
  • 300
  • 400
  • 500
  • 612 a.a.
Protein Preferred Names Protein Names

baculoviral IAP repeat-containing protein 2

  • IAP-2

  • RING-type E3 ubiquitin transferase BIRC2

  • apoptosis inhibitor 2

  • baculoviral IAP repeat-containing 3

  • cellular inhibitor of apoptosis 1

  • inhibitor of apoptosis protein 2

  • mIAP-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-50685 A 410099.1 Inhibitor 99.30% Unkown
HY-RS01507 BIRC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01508 Birc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01509 Birc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01512 Birc3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Birc2 NCBI NCBI:329