2. Gene
  3. App - amyloid beta (A4) precursor protein Gene

App - amyloid beta (A4) precursor protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ag; Abpp; Adap; Cvap; Abeta; betaApp; E030013M08Rik

Gene ID: 11820 | Gene type: protein coding

About App

Chromosome 16: 84,746,573-84,970,654 reverse strand.GRCm39:CM001009.3

This gene has 11 transcripts (splice variants), 280 orthologues, 2 paralogues and is associated with 62 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 142.7), lung adult (RPKM 135.8) and 25 other tissues.

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; low-density lipoprotein particle receptor binding activity; and signaling receptor activator activity. Involved in negative regulation of blood circulation; positive regulation of endothelin production; and positive regulation of tumor necrosis factor production. Acts upstream of or within several processes, including cellular metal ion homeostasis; nervous system development; and regulation of cellular protein metabolic process. Located in several cellular components, including cytoplasmic vesicle; cytoskeleton; and neuromuscular junction. Is integral component of membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; neurogenic placode; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Apr 2022]

App Products(5)

mRNA Protein Name
NM_001198826.1 NP_001185755.1 amyloid-beta precursor protein isoform 6 precursor
NM_007471.3 NP_031497.2 amyloid-beta precursor protein isoform 2 precursor
NM_001198824.1 NP_001185753.1 amyloid-beta precursor protein isoform 3 precursor
NM_001198825.1 NP_001185754.1 amyloid-beta precursor protein isoform 5 precursor
NM_001198823.1 NP_001185752.1 amyloid-beta precursor protein isoform 1 precursor

App Protein Structure

A4_EXTRA

A4_EXTRA: smart00006 (23 - 187)

Kunitz_ABPP-like

Kunitz_ABPP-like: cd22607 (293 - 340)

APP_E2

APP_E2: pfam12925 (365 - 547)

JMTM_Notch_APP

JMTM_Notch_APP: cl41775 (692 - 766)

  • 0
  • 200
  • 400
  • 600
  • 770 a.a.
Protein Preferred Names Protein Names

amyloid-beta precursor protein

amyloid-beta A4 protein

alzheimer disease amyloid A4 protein homolog

alzheimer disease amyloid protein

amyloid beta A4 protein

amyloid precursor protein

amyloidogenic glycoprotein

appican

beta-amyloid precursor protein

protease nexin II

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14537 Latrepirdine dihydrochloride 99.71% Yes
Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-16009 Buntanetap Inhibitor 98.11% Phase 3
HY-10254 Mirdametinib 99.95% Phase 2
HY-50759 Ispinesib 99.62% Phase 2
HY-N0192 Arbutin Inhibitor ≥98.0% Phase 2
HY-106005 MMV390048 Inhibitor 99.17% Phase 2
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99185 Bapineuzumab 96.62% Phase 3
HY-P990078 Remternetug Inhibitor / Phase 3
Pre-clinical Phase
Bioactive Molecules (63)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103490 Takinib 99.31% Unkown
HY-139214 IXA4 Inhibitor 99.16% Unkown
HY-19369 L-685458 99.37% Unkown
HY-12856 GSK503 Inhibitor 99.52% Unkown
HY-135699 TD52 ≥95.0% Unkown
HY-114174 Fmoc-Ala-Glu-Asn-Lys-NH2 99.62% Unkown
HY-108643 CMPD1 Inhibitor 99.86% Unkown
HY-123960A Raphin1 acetate Inhibitor 99.88% Unkown
HY-124832 δ-Secretase inhibitor 11 Inhibitor 99.06% Unkown
HY-129096 IDT307 99.76% Unkown
HY-124322 NB-360 Inhibitor 99.22% Unkown
HY-15294 CZC24832 Inhibitor 99.35% Unkown
HY-18010 PCI 29732 Inhibitor 99.86% Unkown
HY-103374 Phenserine Inhibitor 99.55% Unkown
HY-18292 ARN2966 Inhibitor 99.87% Unkown
HY-50883 BMS 299897 Inhibitor 99.24% Unkown
HY-12989 LDN-91946 Inhibitor 98.70% Unkown
HY-136499 DI-82 98.76% Unkown
HY-126242S Tyk2-IN-7 Inhibitor 99.62% Unkown
HY-120597 SAK3 Activator ≥99.0% Unkown
HY-50882 ELN318463 Inhibitor 99.45% Unkown
HY-153986 AEP-IN-2 / Unkown
HY-19918A Anatabine dicitrate 99.03% Unkown
HY-135699A TD52 dihydrochloride 99.90% Unkown
HY-139973 OAB-14 98.72% Unkown
HY-161110 Aβ42-IN-5 Degrader 98.35% Unkown
HY-117924 AUTEN-67 Inducer / Unkown
HY-131068 BACE-1 inhibitor 2 Inhibitor / Unkown
HY-128585 GNE684 Inhibitor / Unkown
HY-P2551 Biotin-β-Amyloid (17-40) / Unkown
HY-103538 JLK-6 Inhibitor / Unkown
HY-105940 IQB-782 / Unkown
HY-107164 Thiomarinol A Inhibitor / Unkown
HY-108966 Kushenol C Inhibitor / Unkown
HY-123960 Raphin1 Inhibitor / Unkown
HY-126047B (R)-(+)-Anatabine / Unkown
HY-128464 LL320 / Unkown
HY-135618 DHODH-IN-3 Inhibitor / Unkown
HY-136733 Ac-DNLD-CHO Inhibitor / Unkown
HY-144739 BACE1-IN-8 Inhibitor / Unkown
HY-144741 BACE1-IN-9 Inhibitor / Unkown
HY-145286 IMPDH2-IN-2 / Unkown
HY-147672 IleRS-IN-1 Inhibitor / Unkown
HY-147674 Isoleucyl tRNA synthetase-IN-2 Inhibitor / Unkown
HY-149396 FXIIa-IN-1 / Unkown
HY-161109 Aβ42-IN-4 / Unkown
HY-N12249 7-Deoxy-trans-dihydronarciclasine Inhibitor / Unkown
HY-P10163 α-Secretase Substrate II, Fluorogenic / Unkown
HY-P10180 β-Amyloid/A4 Protein Precusor (319-335) / Unkown
HY-P1378 β-Amyloid (1-43)(human) / Unkown
HY-P1378A β-Amyloid (1-43)(human) TFA / Unkown
HY-P1729 M-2420 / Unkown
HY-P1894 β-Amyloid Protein Precursor 770 (135-155) / Unkown
HY-P3779 Amyloid 17-42 Inducer / Unkown
HY-P4553 H-Met-Pro-OH / Unkown
HY-P4919 Mca-SEVNLDAEFK(Dnp) / Unkown
HY-RS00863 APP Human Pre-designed siRNA Set A / Unkown
HY-RS00864 App Mouse Pre-designed siRNA Set A / Unkown
HY-RS00865 App Rat Pre-designed siRNA Set A / Unkown
HY-149397 FXIIa-IN-2 / Unkown
HY-16009B Buntanetap L-Tartrate / Unkown
HY-50882A ELN318463 racemate Inhibitor / Unkown
HY-P4885 Glp-amyloid-β (3-40) peptide (human) / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9999 Trontinemab Inhibitor 96.77% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens App NCBI NCBI:351
Rattus norvegicus App NCBI NCBI:54226