App - amyloid beta (A4) precursor protein Gene

Also Known as Ag; Abpp; Adap; Cvap; Abeta; betaApp; E030013M08Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11820

About App

Chromosome 16: 84,746,573-84,970,654 reverse strand.GRCm39:CM001009.3

This gene has 11 transcripts (splice variants), 280 orthologues, 2 paralogues and is associated with 62 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 142.7), lung adult (RPKM 135.8) and 25 other tissues.

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; low-density lipoprotein particle receptor binding activity; and signaling receptor activator activity. Involved in negative regulation of blood circulation; positive regulation of endothelin production; and positive regulation of tumor necrosis factor production. Acts upstream of or within several processes, including cellular metal ion homeostasis; nervous system development; and regulation of cellular protein metabolic process. Located in several cellular components, including cytoplasmic vesicle; cytoskeleton; and neuromuscular junction. Is integral component of membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; neurogenic placode; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Apr 2022]

App Products (5)

mRNA	Protein	Name
NM_001198826.1	NP_001185755.1	amyloid-beta precursor protein isoform 6 precursor
NM_007471.3	NP_031497.2	amyloid-beta precursor protein isoform 2 precursor
NM_001198824.1	NP_001185753.1	amyloid-beta precursor protein isoform 3 precursor
NM_001198825.1	NP_001185754.1	amyloid-beta precursor protein isoform 5 precursor
NM_001198823.1	NP_001185752.1	amyloid-beta precursor protein isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15944124	MGI
enables low-density lipoprotein particle receptor binding	IPI IPI: Inferred from physical interaction	22383525	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10460257	MGI
enables protein domain specific binding	IDA IDA: Inferred from direct assay	30902970	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	24305806	MGI
enables signaling receptor activator activity	IDA IDA: Inferred from direct assay	11316806	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	15561424	MGI
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	7758106	MGI
acts upstream of or within axo-dendritic transport	IGI IGI: Inferred from genetic interaction	20829454	MGI
NOT acts upstream of or within axo-dendritic transport	IMP IMP: Inferred from mutant phenotype	15745965	MGI
acts upstream of or within axo-dendritic transport	IMP IMP: Inferred from mutant phenotype	11740561	MGI
acts upstream of or within axon midline choice point recognition	IMP IMP: Inferred from mutant phenotype	8001115	MGI
acts upstream of or within axonogenesis	IMP IMP: Inferred from mutant phenotype	9390996	MGI
acts upstream of or within cholesterol metabolic process	IGI IGI: Inferred from genetic interaction	17920016	MGI
acts upstream of or within cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	17920016	MGI
acts upstream of or within cognition	IDA IDA: Inferred from direct assay	25592972	MGI
acts upstream of or within collateral sprouting in absence of injury	IGI IGI: Inferred from genetic interaction	15689559	MGI
acts upstream of or within cytosolic mRNA polyadenylation	IDA IDA: Inferred from direct assay	16314516	MGI
acts upstream of or within dendrite development	IGI IGI: Inferred from genetic interaction	15689559	MGI
acts upstream of or within dendrite development	IMP IMP: Inferred from mutant phenotype	9390996	MGI
acts upstream of or within endocytosis	IMP IMP: Inferred from mutant phenotype	16025111	MGI
acts upstream of or within extracellular matrix organization	IGI IGI: Inferred from genetic interaction	15385965	MGI
acts upstream of or within forebrain development	IGI IGI: Inferred from genetic interaction	15385965	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	8001115	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	30902970	MGI
acts upstream of or within intracellular copper ion homeostasis	IGI IGI: Inferred from genetic interaction	15447675	MGI
acts upstream of or within intracellular copper ion homeostasis	IMP IMP: Inferred from mutant phenotype	10526140	MGI
acts upstream of or within ionotropic glutamate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16025111	MGI
acts upstream of or within locomotory behavior	IGI IGI: Inferred from genetic interaction	9461064	MGI
acts upstream of or within mating behavior	IGI IGI: Inferred from genetic interaction	9461064	MGI
acts upstream of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	15561424	MGI
involved in negative regulation of blood circulation	IGI IGI: Inferred from genetic interaction	12808450	MGI
acts upstream of or within negative regulation of neuron differentiation	IDA IDA: Inferred from direct assay	18278038	MGI
acts upstream of or within negative regulation of neuron differentiation	IGI IGI: Inferred from genetic interaction	18278038	MGI
acts upstream of or within negative regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	30902970	MGI
acts upstream of or within neuromuscular process controlling balance	IGI IGI: Inferred from genetic interaction	9461064	MGI
acts upstream of or within neuron apoptotic process	IGI IGI: Inferred from genetic interaction	16478525	MGI
acts upstream of or within neuron cellular homeostasis	IGI IGI: Inferred from genetic interaction	12431992	MGI
acts upstream of neuron differentiation	IDA IDA: Inferred from direct assay	18278038	MGI
acts upstream of neuron differentiation	IGI IGI: Inferred from genetic interaction	18278038	MGI
acts upstream of or within neuron projection development	IDA IDA: Inferred from direct assay	8083748	MGI
acts upstream of or within neuron remodeling	IMP IMP: Inferred from mutant phenotype	10219973	MGI
acts upstream of or within positive regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	15561424	MGI
involved in positive regulation of endothelin production	IGI IGI: Inferred from genetic interaction	12808450	MGI
acts upstream of or within positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	15561424	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15944124	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15944124	MGI
involved in positive regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	12808450	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	16025111	MGI
acts upstream of or within regulation of epidermal growth factor-activated receptor activity	IGI IGI: Inferred from genetic interaction	17556541	MGI
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	12074840	MGI
acts upstream of or within regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	9754878	MGI
acts upstream of or within regulation of protein binding	IGI IGI: Inferred from genetic interaction	17920016	MGI
acts upstream of or within regulation of protein binding	IMP IMP: Inferred from mutant phenotype	17920016	MGI
acts upstream of or within regulation of synapse structure or activity	IMP IMP: Inferred from mutant phenotype	10219973	MGI
acts upstream of or within regulation of translation	IDA IDA: Inferred from direct assay	16314516	MGI
acts upstream of or within response to oxidative stress	IGI IGI: Inferred from genetic interaction	16478525	MGI
acts upstream of or within smooth endoplasmic reticulum calcium ion homeostasis	IGI IGI: Inferred from genetic interaction	12431992	MGI
acts upstream of or within suckling behavior	IGI IGI: Inferred from genetic interaction	9461064	MGI
acts upstream of or within synaptic assembly at neuromuscular junction	IGI IGI: Inferred from genetic interaction	15689559	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	10338291	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in COPII-coated ER to Golgi transport vesicle	IDA IDA: Inferred from direct assay	19966784	MGI
located in Golgi apparatus	IDA IDA: Inferred from direct assay	16018997	MGI
located in Golgi-associated vesicle	IDA IDA: Inferred from direct assay	23931995	MGI
located in apical part of cell	IDA IDA: Inferred from direct assay	15561424	MGI
located in axon	IDA IDA: Inferred from direct assay	11740561	MGI
is active in axon	IMP IMP: Inferred from mutant phenotype	30902970	MGI
is active in cell surface	IDA IDA: Inferred from direct assay	30902970	MGI
located in cell surface	IDA IDA: Inferred from direct assay	16227578	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	23793062	MGI
located in ciliary rootlet	IDA IDA: Inferred from direct assay	16018997	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10845772	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	11740561	MGI
located in early endosome	IDA IDA: Inferred from direct assay	25592972	MGI
is active in intracellular vesicle	IDA IDA: Inferred from direct assay	30902970	MGI
located in membrane	IDA IDA: Inferred from direct assay	9535056	MGI
located in neuromuscular junction	IDA IDA: Inferred from direct assay	10845772	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	16301330	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	8207383	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15009636	MGI
is active in presynaptic active zone	IDA IDA: Inferred from direct assay	23815291	MGI
is active in presynaptic active zone	IEP IEP: Inferred from expression pattern	23815291	MGI
located in recycling endosome	IDA IDA: Inferred from direct assay	23931995	MGI
located in spindle midzone	IDA IDA: Inferred from direct assay	15561424	MGI
located in synaptic vesicle	IDA IDA: Inferred from direct assay	25438880	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

App Protein Structure

A4_EXTRA

Kunitz_ABPP-like

APP_E2

JMTM_Notch_APP

0
200
400
600
770 a.a.

Protein Preferred Names	Protein Names
amyloid-beta precursor protein amyloid-beta A4 protein	alzheimer disease amyloid A4 protein homolog alzheimer disease amyloid protein amyloid beta A4 protein amyloid precursor protein amyloidogenic glycoprotein appican beta-amyloid precursor protein protease nexin II

Protein Preferred Names

Protein Names

amyloid-beta precursor protein

amyloid-beta A4 protein

alzheimer disease amyloid A4 protein homolog
alzheimer disease amyloid protein
amyloid beta A4 protein
amyloid precursor protein
amyloidogenic glycoprotein
appican
beta-amyloid precursor protein
protease nexin II

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10254	Mirdametinib		99.95%	Unkown
HY-N0192	Arbutin	Inhibitor	99.76%	Unkown
HY-14537	Latrepirdine dihydrochloride		99.65%	Yes
HY-14862	Latrepirdine		99.51%	Yes

Clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-103374	Phenserine	Inhibitor	99.55%	Phase 3
HY-50759	Ispinesib		99.62%	Phase 2
HY-106005	MMV390048	Inhibitor	98.85%	Phase 2
HY-152846	Flizasertib	Inhibitor	99.9%	Phase 2
HY-177646	Mivelsiran	Inhibitor	95.96%	Phase 2
HY-177646A	Mivelsiran sodium	Inhibitor	95.46%	Phase 2
HY-13438	AZD3839 free base	Inhibitor	99.97%	Phase 1
HY-108041	MGS 0210	Agonist	/	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99185	Bapineuzumab		96.62%	Phase 3

Pre-clinical Phase

Bioactive Molecules (112)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103490	Takinib		99.48%	Unkown
HY-139214	IXA4	Inhibitor	98.92%	Unkown
HY-19369	L-685458		99.69%	Unkown
HY-P5381	gp91 ds-tat		99.00%	Unkown
HY-16009	Buntanetap		99.71%	Unkown
HY-123960	Raphin1	Inhibitor	99.74%	Unkown
HY-N1472	Levistolide A		99.34%	Unkown
HY-129096	IDT307		99.74%	Unkown
HY-114174	Fmoc-Ala-Glu-Asn-Lys-NH2		99.55%	Unkown
HY-129430	N-Methylprotoporphyrin IX	Inhibitor	99.0%	Unkown
HY-P6365B	APP-018		99.80%	Unkown
HY-124832	δ-Secretase inhibitor 11	Inhibitor	99.89%	Unkown
HY-120597	SAK3	Activator	99.80%	Unkown
HY-13769A	TPT-260 Dihydrochloride		98.0%	Unkown
HY-135699	TD52		95.0%	Unkown
HY-108643	CMPD1	Inhibitor	99.81%	Unkown
HY-12989	LDN-91946	Inhibitor	98.04%	Unkown
HY-109536B	Ammonium polyphosphate, n<20, water solubility>90 g/100 mL		/	Unkown
HY-50883	BMS 299897	Inhibitor	99.64%	Unkown
HY-15294	CZC24832	Inhibitor	99.07%	Unkown
HY-18292	ARN2966	Inhibitor	98.78%	Unkown
HY-W747599	Ganglioside GQ1b (bovine) sodium		≥98.0%	Unkown
HY-12856	GSK503	Inhibitor	99.52%	Unkown
HY-123960A	Raphin1 acetate	Inhibitor	99.93%	Unkown
HY-161110	APP degrader-1	Degrader	99.11%	Unkown
HY-117924	AUTEN-67	Inducer	97.14%	Unkown
HY-161723	LH2-051	Inhibitor	99.85%	Unkown
HY-126242S	Tyk2-IN-7	Inhibitor	99.58%	Unkown
HY-171347	gamma-secretase modulator 6		99.68%	Unkown
HY-18010	PCI 29732	Inhibitor	99.59%	Unkown
HY-128090A	Apstatin TFA	Inhibitor	99.57%	Unkown
HY-145286	IMPDH2-IN-2		99.89%	Unkown
HY-153986	AEP-IN-2	Inhibitor	99.13%	Unkown
HY-176036	MS1262	Inhibitor	98.61%	Unkown
HY-N3001	Isolinderalactone		98.79%	Unkown
HY-135699A	TD52 dihydrochloride		99.55%	Unkown
HY-139973	OAB-14		99.21%	Unkown
HY-50882	ELN318463	Inhibitor	99.45%	Unkown
HY-N1414A	3′,6-Disinapoylsucrose	Inhibitor	98.88%	Unkown
HY-128585	GNE684	Inhibitor	99.08%	Unkown
HY-108966	Kushenol C	Inhibitor	99.58%	Unkown
HY-128464	LL320	Inhibitor	99.91%	Unkown
HY-P1378A	β-Amyloid (1-43)(human) TFA		95.42%	Unkown
HY-RS00863	APP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-19918A	Anatabine dicitrate		99.03%	Unkown
HY-16009B	Buntanetap L-Tartrate		98.93%	Unkown
HY-174367	RUNX1/ETO-IN-1		91.18%	Unkown
HY-P1894A	β-Amyloid Protein Precursor 770 (135-155) TFA		/	Unkown
HY-P4553A	H-Met-Pro-OH acetate		98.41%	Unkown
HY-131068	BACE-1 inhibitor 2	Inhibitor	/	Unkown
HY-P2551	Biotin-β-Amyloid (17-40)		/	Unkown
HY-103374A	Phenserine tartrate	Inhibitor	/	Unkown
HY-103374B	(±)Phenserine	Inhibitor	/	Unkown
HY-105940	IQB-782		/	Unkown
HY-107164	Thiomarinol A	Inhibitor	/	Unkown
HY-118243	KMS88009	Inhibitor	/	Unkown
HY-118245	APP-FUBINACA	Agonist	/	Unkown
HY-118972	TPI-1917-49	Inhibitor	/	Unkown
HY-125405	AZ3971	Inhibitor	/	Unkown
HY-125472	LC-1028	Inhibitor	/	Unkown
HY-126047B	(R)-(+)-Anatabine		/	Unkown
HY-13438A	AZD3839 fumarate	Inhibitor	/	Unkown
HY-135618	DHODH-IN-3	Inhibitor	/	Unkown
HY-136733	Ac-DNLD-CHO	Inhibitor	/	Unkown
HY-139052	III-31-C	Inhibitor	/	Unkown
HY-144739	BACE1-IN-8	Inhibitor	/	Unkown
HY-144741	BACE1-IN-9	Inhibitor	/	Unkown
HY-147672	IleRS-IN-1	Inhibitor	/	Unkown
HY-147674	Isoleucyl tRNA synthetase-IN-2	Inhibitor	/	Unkown
HY-147927A	(S)-Human enteropeptidase-IN-1	Inhibitor	/	Unkown
HY-149396	FXIIa-IN-1	Inhibitor	/	Unkown
HY-149396A	FXIIa-IN-1 hydrochloride	Inhibitor	/	Unkown
HY-161109	Aβ42-IN-4		/	Unkown
HY-161953	O-GlcNAcase-IN-2	Inhibitor	/	Unkown
HY-168241	Flucopride		/	Unkown
HY-168859	JNK3 inhibitor-9	Inhibitor	/	Unkown
HY-169296	IMPDH2-IN-4	Inhibitor	/	Unkown
HY-176271	MAO-B-IN-45		/	Unkown
HY-176749	HUP-46		/	Unkown
HY-180997	Aβ aggregation-IN-5	Inhibitor	/	Unkown
HY-182050	YL0441	Inhibitor	/	Unkown
HY-182367	TMN-OMe	Agonist	/	Unkown
HY-182429	NB-533	Inhibitor	/	Unkown
HY-183057	GRK2 modulator 1		/	Unkown
HY-19846	VRX-03011	Agonist	/	Unkown
HY-401209	Synucleozid-2.0	Inhibitor	98.01%	Unkown
HY-50759A	Ispinesib mesylate		/	Unkown
HY-N12249	7-Deoxy-trans-dihydronarciclasine	Inhibitor	/	Unkown
HY-N13064	2,2′,4,4′-Tetrahydroxychalcone	Inhibitor	/	Unkown
HY-P10163	α-Secretase Substrate II, Fluorogenic		/	Unkown
HY-P10180	β-Amyloid/A4 Protein Precusor (319-335)		/	Unkown
HY-P10247	Amyloid precursor C-terminal peptide		/	Unkown
HY-P10487	APP669-711		/	Unkown
HY-P1378	β-Amyloid (1-43)(human)		/	Unkown
HY-P1729	M-2420		/	Unkown
HY-P1894	β-Amyloid Protein Precursor 770 (135-155)		/	Unkown
HY-P3779	Amyloid 17-42	Inducer	/	Unkown
HY-P4553	H-Met-Pro-OH		/	Unkown
HY-P4919	Mca-SEVNLDAEFK(Dnp)		/	Unkown
HY-P4926	Mca-SEVKMDAEFRK(Dnp)RR-NH2		/	Unkown
HY-P5274	BACE1 (485-501)		/	Unkown
HY-RS00864	App Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00865	App Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-121817	Sulfiram	Inhibitor	96.35%	Unkown
HY-128090	Apstatin	Inhibitor	/	Unkown
HY-129133	cis-Miyabenol C		/	Unkown
HY-133184	Aminogenistein	Inhibitor	/	Unkown
HY-13769	TPT-260		/	Unkown
HY-149397	FXIIa-IN-2	Inhibitor	/	Unkown
HY-180856	APP modulator-1		/	Unkown
HY-50882A	ELN318463 racemate	Inhibitor	/	Unkown
HY-P4885	Glp-amyloid-β (3-40) peptide (human)		/	Unkown

Inhibitory Antibodies (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990301	Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2)	Inhibitor	95%	Unkown
HY-P991130	Dalidnetug	Ligand	96.686%	Unkown
HY-P992157	Anti-APP/Amyloid beta Antibody (3D6)	Ligand	/	Unkown
HY-P992356	GENA-104A16	Inhibitor	/	Unkown
HY-P992411	MEDI-8490	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	App	NCBI	NCBI:351