TPH2 - tryptophan hydroxylase 2 Gene

Also Known as NTPH; ADHD7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 121278

About TPH2

Cytogenetic location: 12q21.1 Genomic coordinates (GRCh38): 12:71,938,845-72,032,440 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues, 3 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016]

TPH2 Products (1)

mRNA	Protein	Name
NM_173353.4	NP_775489.2	tryptophan 5-hydroxylase 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables tryptophan 5-monooxygenase activity	IDA IDA: Inferred from direct assay	37608910	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPH2 Protein Structure

ACT

Biopterin_H

0
100
200
300
400
490 a.a.

Protein Preferred Names	Protein Names
tryptophan 5-hydroxylase 2	neuronal tryptophan hydroxylase

TPH2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87117	TPH2 Antibody (YA6810)	WB, IHC-P, IHC-F, IP	Mouse, Rat

Related Diseases

Diseases	Alias
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Major Affective Disorder 1	Bipolar Affective Disorder MAFD1 Manic-Depressive Psychosis Md1 Bpad Manic-Depressive Psychosis, Autosomal Bipolar Affective Disorder, Susceptibility To Bipolar Disorder
Personality Disorder	Personality Disorders Character Disorder Personality Specific Personality Disorders Enduring Personality Change After Psychiatric Illness
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Panic Disorder	Panic Anxiety Syndrome Panic Panic Disorder 1 Episodic Paroxysmal Anxiety Disorder
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Sudden Infant Death Syndrome	SIDS Sudden Infant Death Syndrome, Susceptibility To Cot Death Crib Death Sudden Death Of Nonspecific Cause In Infancy Sudden Infant Death Death, Sudden, Syndrome, Infant
Borderline Personality Disorder
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Mood Disorder	Mood Disorders Episodic Mood Disorder
Hypertryptophanemia	HYPTRP Hypertryptophanemia, Familial Familial Hypertryptophanemia
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Schizophrenia 3	SCZD3 Schizophrenia Susceptibility Locus, Chromosome 6-Related Schizophrenia 3 With Or Without An Affective Disorder
Mouth Disease	Mouth Diseases Mouth Disorders
Prader-Willi Syndrome	Prader-Labhart-Willi Syndrome PWS Willi-Prader Syndrome Prader-Willi Syndrome Due To Translocation Prader-Willi Syndrome Due To Imprinting Mutation Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15 Prader Willi Syndrome Upd(15)Mat
Mental Depression	Depression Depressive Disorder
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Endogenous Depression	Clinical Depression Unipolar Depression Depressive Disorder
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W019599	4-Chloro-L-phenylalanine	Inhibitor	98.19%	Unkown
HY-120083	Rodatristat	Inhibitor	98.41%	Unkown
HY-157014	TPT-004	Inhibitor	99.90%	Unkown
HY-181575	TPH2 agonist-1	Inhibitor	/	Unkown
HY-RS14331	TDO2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14933	TPH2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17651	Tph2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24111	Tph2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TPH2	VGNC	VGNC:66474
Bos taurus	TPH2	VGNC	VGNC:56230
Macaca mulatta	TPH2	VGNC	VGNC:79270
Mus musculus	TPH2	MGD	MGI:2651811
Rattus norvegicus	TPH2	RGD	RGD:631332
Canis familiaris	TPH2	VGNC	VGNC:47739
Others	TPH2	NCBI