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H4C16 - H4 histone 16 Gene

Also Known as H4/p; H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4-16; H4C11; H4C12; H4C13; H4C14; H4C15; HIST4H4

Species: Homo sapiens (human)

Gene Type: protein coding

Gene ID: 121504

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]

H4C16 Products (1)

mRNA	Protein	Name
NM_175054.2	NP_778224.1	histone H4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9540062	GOA
enables structural constituent of chromatin	IDA IDA: Inferred from direct assay	14718166	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of megakaryocyte differentiation	IDA IDA: Inferred from direct assay	18474616	GOA
involved in nucleosome assembly	IDA IDA: Inferred from direct assay	14718166	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CENP-A containing nucleosome	IPI IPI: Inferred from physical interaction	21743476	GOA
part of nucleosome	IDA IDA: Inferred from direct assay	14718166	GOA
part of nucleosome	IPI IPI: Inferred from physical interaction	20498094	GOA
located in nucleus	IDA IDA: Inferred from direct assay	14585971	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	14718166	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
histone H4	histone 4, H4 histone cluster 4 H4

H4C16 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	H4C16	P62805	H2BC21	Homo sapiens	Q16778	Crosslink	30021884
Intra	H4C16	P62805	H3-3A	Homo sapiens	P84243	Anti Tag CoIP	24183680
Intra	H4C16	P62805	L3MBTL1	Homo sapiens	Q9Y468	Pull Down	17540172
Intra	H4C16	P62805	L3MBTL1	Homo sapiens	Q9Y468	Pull Down	16415788
Intra	H4C16	P62805	KMT5A	Homo sapiens	Q9NQR1	GMS	21983900
Intra	H4C16	P62805	KMT5A	Homo sapiens	Q9NQR1	Methyltransferase Ass	15933069
Cross	H4C16	P62805	LANA1	Human herpesvirus 8	Q9QR71	Crosslink	31759698
Intra	H4C16	P62805	CENPA	Homo sapiens	P49450	GMS	26167883
Intra	H4C16	P62805	HAT1	Homo sapiens	O14929	TAP	19862764
Intra	H4C16	P62805	PHF20	Homo sapiens	Q9BVI0	Pull Down	16415788
Intra	H4C16	P62805	PHF20L1	Homo sapiens	A8MW92	Protein Array	16415788
Intra	H4C16	P62805	BRPF1	Homo sapiens	P55201	ITC	25281266
Intra	H4C16	P62805	JMJD4	Homo sapiens	Q9H9V9	Demethylase Assay	24360279
Intra	H4C16	P62805	RAN	Homo sapiens	P62826	Crosslink	30021884
Intra	H4C16	P62805	HDAC1	Homo sapiens	Q13547	GMS	21983900
Intra	H4C16	P62805	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	H4C16	P62805	PRMT5	Homo sapiens	O14744	Methyltransferase Ass	20951943
Intra	H4C16	P62805	RBBP7	Homo sapiens	Q16576	X-Ray Diffraction	18571423
Intra	H4C16	P62805	RBBP7	Homo sapiens	Q16576	Pull Down	18571423
Intra	H4C16	P62805	RBBP7	Homo sapiens	Q16576	TAP	19862764
Intra	H4C16	P62805	RBBP7	Homo sapiens	Q16576	Anti Tag CoIP	28514442
Intra	H4C16	P62805	RBBP7	Homo sapiens	Q16576	SPR	18571423
Intra	H4C16	P62805	SMARCA5	Homo sapiens	O60264	Anti Bait CoIP	16917504
Intra	H4C16	P62805	SMARCA5	Homo sapiens	O60264	Pull Down	16917504
Intra	H4C16	P62805	MCM3	Homo sapiens	P25205	TAP	19862764
Intra	H4C16	P62805	MCM3	Homo sapiens	P25205	Anti Bait CoIP	19862764
Intra	H4C16	P62805	SMARCB1	Homo sapiens	Q12824	Crosslink	31759698
Intra	H4C16	P62805	H3-4	Homo sapiens	Q16695	Crosslink	30021884
Intra	H4C16	P62805	H2AC4	Homo sapiens	P04908	Crosslink	30021884
Intra	H4C16	P62805	MCM5	Homo sapiens	P33992	Anti Bait CoIP	19862764
Intra	H4C16	P62805	MCM5	Homo sapiens	P33992	TAP	19862764
Intra	H4C16	P62805	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	H4C16	P62805	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	H4C16	P62805	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	H4C16	P62805	MCM2	Homo sapiens	P49736	TAP	19862764
Intra	H4C16	P62805	MCM2	Homo sapiens	P49736	Anti Tag CoIP	28514442
Intra	H4C16	P62805	TP53BP1	Homo sapiens	Q12888	Pull Down	23377543
Intra	H4C16	P62805	TP53BP1	Homo sapiens	Q12888	Pull Down	16415788
Intra	H4C16	P62805	TP53BP1	Homo sapiens	Q12888	ITC	22373579
Intra	H4C16	P62805	TP53BP1	Homo sapiens	Q12888	Pull Down	27153538
Intra	H4C16	P62805	TP53BP1	Homo sapiens	Q12888	NMR	23377543
Intra	H4C16	P62805	BPTF	Homo sapiens	Q12830-4	Pull Down	21596426
Intra	H4C16	P62805	BPTF	Homo sapiens	Q12830-4	Peptide Array	21596426
Intra	H4C16	P62805	H2AX	Homo sapiens	P16104	Crosslink	30021884
Intra	H4C16	P62805	RRP1B	Homo sapiens	Q14684-1	Confocal	19710015
Intra	H4C16	P62805	RRP1B	Homo sapiens	Q14684-1	Anti Tag CoIP	19710015
Intra	H4C16	P62805	MBTD1	Homo sapiens	Q05BQ5	Pull Down	27153538
Intra	H4C16	P62805	TLE1	Homo sapiens	Q04724	Far-WB	24596249
Intra	H4C16	P62805	HMGA1	Homo sapiens	P17096	Crosslink	30021884
Intra	H4C16	P62805	ASF1A	Homo sapiens	Q9Y294	Validated Y2H	25416956
Intra	H4C16	P62805	ASF1A	Homo sapiens	Q9Y294	Y2H Array	32296183
Intra	H4C16	P62805	ASF1A	Homo sapiens	Q9Y294	Y2H Array	25416956
Intra	H4C16	P62805	ASF1A	Homo sapiens	Q9Y294	Y2H Prey Pooling	32296183
Intra	H4C16	P62805	ASF1A	Homo sapiens	Q9Y294	TAP	19862764
Intra	H4C16	P62805	ASF1A	Homo sapiens	Q9Y294	Complementation	32296183
Intra	H4C16	P62805	ASF1A	Homo sapiens	Q9Y294	Validated Y2H	32296183
Intra	H4C16	P62805	H3C13	Homo sapiens	Q71DI3	Crosslink	30021884
Intra	H4C16	P62805	PRMT1	Homo sapiens	Q99873	Methyltransferase Ass	24726341
Intra	H4C16	P62805	H3C1	Homo sapiens	P68431	GMS	20498094
Intra	H4C16	P62805	H3C1	Homo sapiens	P68431	SAXS	20739937
Intra	H4C16	P62805	H3C1	Homo sapiens	P68431	DLS	20498094
Intra	H4C16	P62805	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	H4C16	P62805	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	H4C16	P62805	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	H4C16	P62805	BRD4	Homo sapiens	O60885-1	Pull Down	24525235
Intra	H4C16	P62805	BRD4	Homo sapiens	O60885-1	Fluorescence Spectr	24361270
Intra	H4C16	P62805	BRD4	Homo sapiens	O60885-1	Anti Bait CoIP	24525235
Intra	H4C16	P62805	KDM4A	Homo sapiens	O75164	ITC	22373579
Cross	H4C16	P62805	Sfmbt	Drosophila melanogaster	Q9VK33	ITC	19494831

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant H4C16 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72336	Histone H4 Protein, Human/Xenopus laevis	P62805 (S2-G103)	≥ 95%, as determined by reducing SDS-PAGE.

H4C16 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80178	Histone H4 Antibody (YA363)	WB, IHC-P, ICC/IF, ChIP, IF-Tissue	Human, Mouse, Rat
HY-P80179	Histone H4 (acetyl K16) Antibody (YA366)	WB, IHC-P, FC, ICC/IF	Human, Mouse, Rat
HY-P80180	Histone H4 (acetyl K8) Antibody (YA365)	WB, IHC-P, ICC/IF, ChIP	Human, Mouse, Rat
HY-P80181	Histone H4 (tri methyl K20) Antibody (YA364)	WB, IHC-P	Human, Mouse
HY-P80182	Histone H4 (acetyl K5) Antibody (YA362)	WB, ICC/IF, IHC-P, IP, ChIP	Human, Mouse, Rat
HY-P81256	Acetyl-Histone H4 Antibody (YA926)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P81256A	Acetyl-Histone H4 Antibody (YA927)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P83301	MonoMethyl-Histone H4 (Lys16) Antibody (YA3046)	WB, ICC/IF	Human, Mouse
HY-P86642	Histone H4 Antibody (YA6334)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05974	H4C1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05975	H4C2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05976	H4C3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05977	H4C4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05978	H4C6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05979	H4C8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19607	H4c1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown