Bub3 - BUB3 mitotic checkpoint protein Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12237

Summary

This gene encodes a component of the mitotic spindle assembly complex. The encoded protein is involved in the regulation of chromosome segregation during oocyte meiosis. Disruption of this gene results in the accumulation of mitotic errors and is lethal in the embryonic stage. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

Bub3 Products (3)

mRNA Protein Name
NM_001317350.2 NP_001304279.1 mitotic checkpoint protein BUB3 isoform a
NM_001411927.1 NP_001398856.1 mitotic checkpoint protein BUB3 isoform b
NM_009774.5 NP_033904.2 mitotic checkpoint protein BUB3 isoform a

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in regulation of chromosome segregation IDA
IDA: Inferred from direct assay
19888327 MGI
Cellular Component GO Annotation Evidence References Source
located in kinetochore IDA
IDA: Inferred from direct assay
35167144 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitotic checkpoint protein BUB3

  • WD repeat type I transmembrane protein A72.5

  • budding uninhibited by benzimidazoles 3 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01683 BUB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21302 Bub3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27821 Bub3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bub3 NCBI NCBI:9184