PLIN2 - perilipin 2 Gene

Also Known as ADFP; ADRP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 123

About PLIN2

Cytogenetic location: 9p22.1 Genomic coordinates (GRCh38): 9:19,108,388-19,127,492 (from NCBI)

This gene has 8 transcripts (splice variants), 226 orthologues and 4 paralogues. Broad expression in liver (RPKM 234.7), placenta (RPKM 77.4) and 16 other tissues.

Summary

The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]

PLIN2 Products (1)

mRNA	Protein	Name
NM_001122.4	NP_001113.2	perilipin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cellular response to glucose starvation	IDA IDA: Inferred from direct assay	34077757	GOA
involved in lipid droplet disassembly	IDA IDA: Inferred from direct assay	34077757	GOA
involved in lipid storage	IDA IDA: Inferred from direct assay	34077757	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in lipid droplet	IDA IDA: Inferred from direct assay	14741744	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLIN2 Protein Structure

Perilipin

0
100
200
300
400
437 a.a.

Protein Preferred Names	Protein Names
perilipin-2	adipophilin

PLIN2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	PLIN2	Q99541	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	PLIN2	Q99541	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	PLIN2	Q99541	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	PLIN2	Q99541	DESI2	Homo sapiens	Q9BSY9	Y2H Prey Pooling	32296183
Intra	PLIN2	Q99541	DESI2	Homo sapiens	Q9BSY9	Validated Y2H	32296183
Intra	PLIN2	Q99541	DESI2	Homo sapiens	Q9BSY9	Y2H Array	32296183
Intra	PLIN2	Q99541	HTATIP2	Homo sapiens	Q9BUP3-3	Y2H Prey Pooling	32296183
Intra	PLIN2	Q99541	HTATIP2	Homo sapiens	Q9BUP3-3	Y2H Array	32296183
Intra	PLIN2	Q99541	HTATIP2	Homo sapiens	Q9BUP3-3	Validated Y2H	32296183
Intra	PLIN2	Q99541	ABHD5	Homo sapiens	Q8WTS1	Y2H Array	32296183
Intra	PLIN2	Q99541	ABHD5	Homo sapiens	Q8WTS1	Y2H Prey Pooling	32296183
Intra	PLIN2	Q99541	SFT2D2	Homo sapiens	O95562	Y2H Prey Pooling	32296183
Intra	PLIN2	Q99541	SFT2D2	Homo sapiens	O95562	Y2H Array	32296183
Intra	PLIN2	Q99541	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	PLIN2	Q99541	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	PLIN2	Q99541	WFS1	Homo sapiens	O76024	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

PLIN2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P84749	Perilipin 2 Antibody (YA4446)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P84749A	Perilipin 2 Antibody (YA4446)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Sebaceous Adenocarcinoma	Sebaceous Carcinoma Adenocarcinoma Of The Sebaceous Gland Malignant Neoplasm Of Sebaceous Gland Malignant Sebaceous Tumor Adenocarcinoma, Sebaceous Malignant Sebaceous Neoplasm Sebaceous Gland Neoplasms
Chanarin-Dorfman Syndrome	Neutral Lipid Storage Disease CDS Neutral Lipid Storage Disease With Ichthyosis Triglyceride Storage Disease With Impaired Long-Chain Fatty Acid Oxidation Triglyceride Storage Disease With Ichthyosis Nlsdi Ichthyotic Neutral Lipid Storage Disease Dorfman-Chanarin Syndrome Dcs Chanarin-Dorfman Disease Ichthyosiform Erythroderma With Leukocyte Vacuolation Lipidosis With Triglyceride Storage Disease Disorder Of Cornification 12 Dorfman Chanarin Syndrome Neutral Lipid Storage Disease With Ichthyotic Dorfman-Chanarin Disease
Meibomian Cyst	Chalazion Meibomian Gland Lipogranuloma Tarsal Cyst
Eyelid Benign Neoplasm	Tumor Of The Eyelid Eyelid Neoplasms Eyelid Neoplasm
Lipid-Rich Carcinoma
Sebaceous Gland Neoplasm	Sebaceous Gland Neoplasms Sebaceous Neoplasm
Alcoholic Liver Cirrhosis	Alcoholic Cirrhosis Portal Cirrhosis Alcoholic Cirrhosis Of Liver Liver Cirrhosis, Alcoholic Laennec'S Cirrhosis Laennec'S Cirrhosis, Alcoholic Alcohol Cirrhosis Alcoholic Laennec Cirrhosis Alcoholic Cirrhosis Nos Etoh Cirrhosis Alcohol Hepatic Cirrhosis Alcohol Liver Cirrhosis Laennec Cirrhosis
Sebaceous Adenoma	Adenoma Of The Sebaceous Gland Skin Appendage Sebaceous Adenoma
Acrodermatitis
Kidney Cancer	Renal Cancer Renal Carcinoma Kidney Neoplasm Malignant Neoplasm Of Kidney Except Pelvis Malignant Tumour Of Kidney Kidney Neoplasms Cancer, Kidney Cancer, Renal Malignant Neoplasm Of Kidney Renal Cell Carcinoma
Muir-Torre Syndrome	MRTES Keratoacanthoma Muir-Torré Syndrome Cutaneous Sebaceous Neoplasms And Keratoacanthomas, Multiple, With Gastrointestinal And Other Carcinomas Cutaneous Sebaceous Neoplasms And Keratoacanthomas Multiple With Gastrointestinal And Other Carcinomas Multiple Keratoacanthoma, Muir-Torre Type Mts Torre-Muir Syndrome
Aggressive Digital Papillary Adenocarcinoma
Adenoid Basal Cell Carcinoma	Skin Adenoid Basal Cell Carcinoma Basal Cell Carcinoma - Adenoid
Blepharoconjunctivitis
Sebaceous Gland Disease	Sebaceous Gland Anomaly Sebaceous Gland Diseases
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Diabetes Mellitus	Diabetes
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS10707	PLIN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18542	Plin2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-124655	S1PL-IN- 2		/	Unkown
HY-138198A	YIC-C8-434	Inhibitor	/	Unkown
HY-RS25024	Plin2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PLIN2	MGD	MGI:87920
Canis familiaris	PLIN2	VGNC	VGNC:44691
Felis catus	PLIN2	VGNC	VGNC:64240
Bos taurus	PLIN2	VGNC	VGNC:33030
Rattus norvegicus	PLIN2	RGD	RGD:728889
Others	PLIN2	NCBI