Cbln1 - cerebellin 1 precursor protein Gene

Mus musculus

Gene ID: 12404 | Gene type: protein coding

About Cbln1

Summary

Enables identical protein binding activity. Involved in several processes, including cerebellar granule cell differentiation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and regulation of synapse assembly. Acts upstream of or within positive regulation of synapse assembly and protein secretion. Located in several cellular components, including glutamatergic synapse; parallel fiber to Purkinje cell synapse; and synaptic cleft. Is expressed in several structures, including central nervous system; limb; oral region epithelium; reproductive system; and sensory organ. Orthologous to human CBLN1 (cerebellin 1 precursor). [provided by Alliance of Genome Resources, Apr 2022]

Cbln1 Products(1)

mRNA	Protein	Name
NM_019626.3	NP_062600.2	cerebellin-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	10964938	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10964938	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cerebellar granule cell differentiation	IGI IGI: Inferred from genetic interaction	20537373	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	17030622	MGI
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IGI IGI: Inferred from genetic interaction	20537373	MGI
involved in maintenance of synapse structure	IMP IMP: Inferred from mutant phenotype	29691328	MGI
involved in negative regulation of inhibitory synapse assembly	IMP IMP: Inferred from mutant phenotype	24467251	MGI
acts upstream of or within positive regulation of synapse assembly	IDA IDA: Inferred from direct assay	21356198	MGI
acts upstream of or within positive regulation of synapse assembly	IGI IGI: Inferred from genetic interaction	21356198	MGI
acts upstream of or within protein secretion	IMP IMP: Inferred from mutant phenotype	17030622	MGI
involved in regulation of postsynaptic density assembly	IDA IDA: Inferred from direct assay	20395510	MGI
involved in regulation of postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	20395510	MGI
involved in regulation of presynapse assembly	IDA IDA: Inferred from direct assay	20395510	MGI
involved in regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	20395510	MGI
acts upstream of synapse assembly	IDA IDA: Inferred from direct assay	21356198	MGI
acts upstream of synapse assembly	IGI IGI: Inferred from genetic interaction	21356198	MGI
involved in synapse organization	IMP IMP: Inferred from mutant phenotype	29691328	MGI
involved in trans-synaptic signaling, modulating synaptic transmission	IDA IDA: Inferred from direct assay	36205393	MGI
involved in trans-synaptic signaling, modulating synaptic transmission	IEP IEP: Inferred from expression pattern	36205393	MGI
involved in trans-synaptic signaling, modulating synaptic transmission	IMP IMP: Inferred from mutant phenotype	36205393	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	29782851	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20395510	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	36205393	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20395510	MGI
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	19250438	MGI
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	19200061	MGI
located in synapse	IDA IDA: Inferred from direct assay	17331201	MGI
is active in synaptic cleft	IDA IDA: Inferred from direct assay	19250438	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cerebellin-1

brain protein D3

precerebellin

Cbln1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Cbln1	Q9R171	Grid2	Mus musculus	Q61625	IF	20537373
Intra	Cbln1	Q9R171	Nrxn1	Mus musculus	P0DI97	Pull Down	20537373
Intra	Cbln1	Q9R171	Nrxn1	Mus musculus	P0DI97	SPR	20537373
Intra	Cbln1	Q9R171	Nrxn1	Mus musculus	P0DI97	IF	20537373

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02001	CBLN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cbln1	NCBI	NCBI:869

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