Cbln1 - cerebellin 1 precursor protein Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12404

Summary

Enables identical protein binding activity. Involved in several processes, including cerebellar granule cell differentiation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and regulation of synapse assembly. Acts upstream of or within positive regulation of synapse assembly and protein secretion. Located in several cellular components, including glutamatergic synapse; parallel fiber to Purkinje cell synapse; and synaptic cleft. Is expressed in several structures, including central nervous system; limb; oral region epithelium; reproductive system; and sensory organ. Orthologous to human CBLN1 (cerebellin 1 precursor). [provided by Alliance of Genome Resources, Apr 2022]

Cbln1 Products (1)

mRNA Protein Name
NM_019626.3 NP_062600.2 cerebellin-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
10964938 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10964938 MGI
Biological Process GO Annotation Evidence References Source
involved in cerebellar granule cell differentiation IGI
IGI: Inferred from genetic interaction
20537373 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
17030622 MGI
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IGI
IGI: Inferred from genetic interaction
20537373 MGI
involved in maintenance of synapse structure IMP
IMP: Inferred from mutant phenotype
29691328 MGI
involved in negative regulation of inhibitory synapse assembly IMP
IMP: Inferred from mutant phenotype
24467251 MGI
acts upstream of or within positive regulation of synapse assembly IDA
IDA: Inferred from direct assay
21356198 MGI
acts upstream of or within positive regulation of synapse assembly IGI
IGI: Inferred from genetic interaction
21356198 MGI
acts upstream of or within protein secretion IMP
IMP: Inferred from mutant phenotype
17030622 MGI
involved in regulation of postsynaptic density assembly IDA
IDA: Inferred from direct assay
20395510 MGI
involved in regulation of postsynaptic density assembly IMP
IMP: Inferred from mutant phenotype
20395510 MGI
involved in regulation of presynapse assembly IDA
IDA: Inferred from direct assay
20395510 MGI
involved in regulation of presynapse assembly IMP
IMP: Inferred from mutant phenotype
20395510 MGI
acts upstream of synapse assembly IDA
IDA: Inferred from direct assay
21356198 MGI
acts upstream of synapse assembly IGI
IGI: Inferred from genetic interaction
21356198 MGI
involved in synapse organization IMP
IMP: Inferred from mutant phenotype
29691328 MGI
involved in trans-synaptic signaling, modulating synaptic transmission IDA
IDA: Inferred from direct assay
36205393 MGI
involved in trans-synaptic signaling, modulating synaptic transmission IEP
IEP: Inferred from expression pattern
36205393 MGI
involved in trans-synaptic signaling, modulating synaptic transmission IMP
IMP: Inferred from mutant phenotype
36205393 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
29782851 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20395510 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
36205393 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
20395510 MGI
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
19250438 MGI
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
19200061 MGI
located in synapse IDA
IDA: Inferred from direct assay
17331201 MGI
is active in synaptic cleft IDA
IDA: Inferred from direct assay
19250438 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cerebellin-1

  • brain protein D3

  • precerebellin

Cbln1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cbln1 Q9R171 Grid2 Mus musculus Q61625
IF
20537373
Intra
Cbln1 Q9R171 Nrxn1 Mus musculus P0DI97
Pull Down
20537373
Intra
Cbln1 Q9R171 Nrxn1 Mus musculus P0DI97
SPR
20537373
Intra
Cbln1 Q9R171 Nrxn1 Mus musculus P0DI97
IF
20537373
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02001 CBLN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cbln1 NCBI NCBI:869