ZC3H18 - zinc finger CCCH-type containing 18 Gene

Also Known as NHN1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 124245

About ZC3H18

This gene has 12 transcripts (splice variants), 205 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 13.0), spleen (RPKM 10.3) and 25 other tissues.

Summary

Enables mRNA cap binding complex binding activity and protein-macromolecule adaptor activity. Involved in RNA destabilization. Located in nuclear speck. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]

ZC3H18 Products (2)

mRNA Protein Name
NM_001294340.2 NP_001281269.1 zinc finger CCCH domain-containing protein 18 isoform 1
NM_144604.4 NP_653205.3 zinc finger CCCH domain-containing protein 18 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA cap binding complex binding IDA
IDA: Inferred from direct assay
28297668 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
28297668 GOA
Biological Process GO Annotation Evidence References Source
involved in RNA destabilization IMP
IMP: Inferred from mutant phenotype
28297668 GOA
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
23793891 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
28297668 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger CCCH domain-containing protein 18

  • conserved nuclear protein NHN1

ZC3H18 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
ZC3H18 Q86VM9 E SARS-CoV-2 P0DTC4
Y2H Array
36217030
Intra
ZC3H18 Q86VM9 TERF2 Homo sapiens Q15554
Pull Down
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11745 RBM27 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15991 ZC3H18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ZC3H18 VGNC VGNC:37104
Rattus norvegicus ZC3H18 RGD RGD:1303257
Canis familiaris ZC3H18 VGNC VGNC:48557
Mus musculus ZC3H18 MGD MGI:1923264
Macaca mulatta ZC3H18 VGNC VGNC:79473
Others ZC3H18 NCBI