Cckbr - cholecystokinin B receptor Gene

Mus musculus

Also known as CCK2R; CCK-BR; CCK2-R; CCKR-2

Gene ID: 12426 | Gene type: protein coding

About Cckbr

Chromosome 7: 105,074,938-105,120,105 forward strand.GRCm39:CM001000.3

This gene has 2 transcripts (splice variants), 268 orthologues, 16 paralogues and is associated with 37 phenotypes. Biased expression in cortex adult (RPKM 23.1), frontal lobe adult (RPKM 18.4) and 3 other tissues.

Summary

This gene encodes a multipass transmembrane receptor protein expressed in the central nervous system and gastrointestinal tract. Cholecystokinin and Gastrin bind to the encoded protein to stimulate gastric acid secretion and mucosal growth in the gastrointestinal tract, and anxiety, pain sensation and memory in the brain. Mice lacking the encoded protein exhibit an increase in the basal gastric pH and Gastrin levels in the bloodstream as well as mild hypocalcemia, secondary hyperparathyroidism and increased bone resorption. [provided by RefSeq, Apr 2015]

Cckbr Products(2)

mRNA	Protein	Name
NM_007627.6	NP_031653.1	gastrin/cholecystokinin type B receptor isoform 1
NM_001412224.1	NP_001399153.1	gastrin/cholecystokinin type B receptor isoform 2

Cckbr Protein Structure

7tm_GPCRs

0
100
200
300
400
453 a.a.

Protein Preferred Names

Protein Names

gastrin/cholecystokinin type B receptor

CCK-B receptor	CCK-B/gastrin receptor
CCK2/gastrin receptor	cholecystokinin-2 receptor

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-A0261	Pentagastrin	Activator	99.97%	Unkown

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1097	Gastrin I, human		99.93%	Unkown
HY-106840	L-365260	Antagonist	99.93%	Unkown
HY-111313	JNJ-26070109	Antagonist	/	Unkown
HY-129810	PD 135158	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cckbr	NCBI	NCBI:887

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