Cckbr - cholecystokinin B receptor Gene

Also Known as CCK2R; CCK-BR; CCK2-R; CCKR-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12426

About Cckbr

Chromosome 7: 105,074,938-105,120,105 forward strand.GRCm39:CM001000.3

This gene has 2 transcripts (splice variants), 268 orthologues, 16 paralogues and is associated with 37 phenotypes. Biased expression in cortex adult (RPKM 23.1), frontal lobe adult (RPKM 18.4) and 3 other tissues.

Summary

This gene encodes a multipass transmembrane receptor protein expressed in the central nervous system and gastrointestinal tract. Cholecystokinin and Gastrin bind to the encoded protein to stimulate gastric acid secretion and mucosal growth in the gastrointestinal tract, and anxiety, pain sensation and memory in the brain. Mice lacking the encoded protein exhibit an increase in the basal gastric pH and Gastrin levels in the bloodstream as well as mild hypocalcemia, secondary hyperparathyroidism and increased bone resorption. [provided by RefSeq, Apr 2015]

Cckbr Products (2)

mRNA Protein Name
NM_007627.6 NP_031653.1 gastrin/cholecystokinin type B receptor isoform 1
NM_001412224.1 NP_001399153.1 gastrin/cholecystokinin type B receptor isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
8876222 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within digestive tract development IMP
IMP: Inferred from mutant phenotype
15476751 MGI
acts upstream of or within gastric acid secretion IGI
IGI: Inferred from genetic interaction
15476751 MGI
acts upstream of or within gastric acid secretion IMP
IMP: Inferred from mutant phenotype
15476751 MGI
acts upstream of or within gland development IMP
IMP: Inferred from mutant phenotype
15476751 MGI
acts upstream of or within pH reduction IMP
IMP: Inferred from mutant phenotype
19448635 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
8876222 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cckbr Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (54 - 406)

7tm_GPCRs

7tm_GPCRs: cd14964 (56 - 80)

7tm_GPCRs

7tm_GPCRs: cd14964 (89 - 111)

7tm_GPCRs

7tm_GPCRs: cd14964 (127 - 149)

7tm_GPCRs

7tm_GPCRs: cd14964 (172 - 188)

7tm_GPCRs

7tm_GPCRs: cd14964 (215 - 238)

7tm_GPCRs

7tm_GPCRs: cd14964 (337 - 359)

7tm_GPCRs

7tm_GPCRs: cd14964 (374 - 399)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 453 a.a.
Protein Preferred Names Protein Names

gastrin/cholecystokinin type B receptor

  • CCK-B receptor

  • CCK-B/gastrin receptor

  • CCK2/gastrin receptor

  • cholecystokinin-2 receptor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0261 Pentagastrin Agonist 99.97% Unkown
HY-A0261A Pentagastrin meglumine Agonist / Unkown

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-19445 Gastrazole Antagonist / Phase 3
HY-106840 L-365260 Antagonist 99.85% Phase 2
HY-14850 Sograzepide Antagonist 98.04% Phase 2
HY-17617 Nastorazepide Antagonist 99.95% Phase 2
HY-105257 Pranazepide Antagonist 99.81% Phase 2
HY-106347 Itriglumide Antagonist / Phase 2
HY-19290 S-0509 Antagonist / Phase 2

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1097 Gastrin I, human 99.93% Unkown
HY-P11540 CCKBR agonist-1 Agonist 98.48% Unkown
HY-111313 JNJ-26070109 Antagonist 99.25% Unkown
HY-129357 CCK-B Receptor Antagonist 2 Inhibitor 98.84% Unkown
HY-155205 GV150013X Antagonist 99.75% Unkown
HY-177506 FE100726 Agonist / Unkown
HY-186122 CCK2R agonist-1 Agonist / Unkown
HY-129810 PD 135158 Antagonist / Unkown
HY-177509 BBL454 Agonist / Unkown
HY-177508 BC264 Agonist / Unkown
HY-119127 TP-680 Antagonist / Unkown
HY-123434 PD-149164 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cckbr NCBI NCBI:887