Cish - cytokine inducible SH2-containing protein Gene

Also Known as Cis; F17; F23; CIS1; SOCS; CIS-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12700

Summary

Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Acts upstream of or within protein kinase C-activating G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in liver; retina; and thymus primordium. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human CISH (cytokine inducible SH2 containing protein). [provided by Alliance of Genome Resources, Apr 2022]

Cish Products (2)

mRNA Protein Name
NM_001317354.1 NP_001304283.1 cytokine-inducible SH2-containing protein isoform 2
NM_009895.4 NP_034025.1 cytokine-inducible SH2-containing protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11781573 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
12618484 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
12618484 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytokine-inducible SH2-containing protein

  • cytokine-inducible SH2 protein

  • suppressor of cytokine signaling

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156395 MN551 Inducer 98.01% Unkown
HY-173364 EB-TCIP Inducer 99.58% Unkown
HY-RS02726 CISH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19885 Cish Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26385 Cish Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cish NCBI NCBI:1154