AADAC - arylacetamide deacetylase Gene

Also Known as DAC; CES5A1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 13

About AADAC

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:151,814,116-151,828,488 (from NCBI)

This gene has 2 transcripts (splice variants), 214 orthologues and 5 paralogues. Biased expression in liver (RPKM 174.6), small intestine (RPKM 100.2) and 4 other tissues.

Summary

Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]

AADAC Products (1)

mRNA	Protein	Name
NM_001086.3	NP_001077.2	arylacetamide deacetylase

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables deacetylase activity	IDA IDA: Inferred from direct assay	9665742	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables serine hydrolase activity	IDA IDA: Inferred from direct assay	17936933	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	10318829	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AADAC Protein Structure

Abhydrolase_3

0
100
200
300
399 a.a.

Protein Preferred Names	Protein Names
arylacetamide deacetylase	arylacetamide deacetylase (esterase)

AADAC Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AADAC	P22760	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	32296183
Intra	AADAC	P22760	APPBP2	Homo sapiens	Q92624	Validated Y2H	32296183
Intra	AADAC	P22760	APPBP2	Homo sapiens	Q92624	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chronic Tic Disorder	Chronic Motor Or Vocal Tic Disorder Tic Disorders Tic Disorder Tic Disorder Nos Tic Nos Tic Spasm Nos
Tic Disorder	Tics Behavioral Tic
Gilles De La Tourette Syndrome	Tourette Syndrome Tourette Disorder GTS Ts Gilles De La Tourette'S Syndrome Motor-Verbal Tic Disorder Guinon'S Disease Psychogenic Tics Tourette'S Syndrome Chronic Motor And Vocal Tic Disorder Td Tourette'S Disease Combined Vocal And Multiple Motor Tic Disorder [De La Tourette] Combined Vocal And Multiple Motor Tic Disorder Tic De La Tourette

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00017	AADAC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18798	Aadac Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25287	Aadac Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	AADAC	VGNC	VGNC:81172
Mus musculus	AADAC	MGD	MGI:1915008
Canis familiaris	AADAC	VGNC	VGNC:37404
Rattus norvegicus	AADAC	RGD	RGD:631440
Others	AADAC	NCBI