Ctsd - cathepsin D Gene

Also Known as CD; CatD

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13033

About Ctsd

Chromosome 7: 141,929,648-141,941,775 reverse strand.GRCm39:CM001000.3

This gene has 3 transcripts (splice variants), 211 orthologues, 8 paralogues and is associated with 42 phenotypes. Broad expression in subcutaneous fat pad adult (RPKM 1266.1), mammary gland adult (RPKM 682.4) and 23 other tissues.

Summary

Enables aspartic-type endopeptidase activity. Acts upstream of or within autophagosome assembly. Located in extracellular space and lysosome. Is expressed in several structures, including central nervous system; extraembryonic component; eye; genitourinary system; and optic nerve. Used to study neuronal ceroid lipofuscinosis 10. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Orthologous to human CTSD (Cathepsin D). [provided by Alliance of Genome Resources, Apr 2022]

Ctsd Products (1)

mRNA Protein Name
NM_009983.3 NP_034113.1 cathepsin D precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aspartic-type endopeptidase activity IDA
IDA: Inferred from direct assay
19293336 MGI
enables aspartic-type peptidase activity IMP
IMP: Inferred from mutant phenotype
16997486 MGI
enables endopeptidase activity IDA
IDA: Inferred from direct assay
26467158 MGI
enables hydrolase activity IDA
IDA: Inferred from direct assay
19710420 MGI
enables peptidase activity IDA
IDA: Inferred from direct assay
15588329 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
28453791 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within autophagosome assembly IMP
IMP: Inferred from mutant phenotype
15452145 MGI
NOT involved in epithelial tube branching involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
17500053 MGI
involved in insulin catabolic process IDA
IDA: Inferred from direct assay
27703010 MGI
involved in insulin receptor recycling IDA
IDA: Inferred from direct assay
27703010 MGI
Cellular Component GO Annotation Evidence References Source
is active in endosome lumen IDA
IDA: Inferred from direct assay
27703010 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
19710420 MGI
located in lysosome IDA
IDA: Inferred from direct assay
9034150 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctsd Protein Structure

A1_Propeptide

A1_Propeptide: pfam07966 (20 - 48)

Cathepsin_D2

Cathepsin_D2: cd05490 (72 - 404)

  • 0
  • 100
  • 200
  • 300
  • 410 a.a.
Protein Preferred Names Protein Names

cathepsin D

Recombinant Ctsd Proteins

Cat. No. Product Name Accession Purity
HY-P7749 Cathepsin D Protein, Mouse (HEK293, His) P18242 (I21-L410) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P2750 Cathepsin D / Unkown
HY-RS03329 Ctsd Mouse Pre-designed siRNA Set A / Unkown
HY-P11844 NOTA-FZCD-3 Ligand / Unkown
HY-RS03328 CTSD Human Pre-designed siRNA Set A / Unkown
HY-176548 PY-PAP / Unkown
HY-RS03330 Ctsd Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctsd NCBI NCBI:1509