Ctsd - cathepsin D Gene

Mus musculus

Also known as CD; CatD

Gene ID: 13033 | Gene type: protein coding

About Ctsd

Chromosome 7: 141,929,648-141,941,775 reverse strand.GRCm39:CM001000.3

This gene has 3 transcripts (splice variants), 211 orthologues, 8 paralogues and is associated with 42 phenotypes. Broad expression in subcutaneous fat pad adult (RPKM 1266.1), mammary gland adult (RPKM 682.4) and 23 other tissues.

Summary

Enables aspartic-type endopeptidase activity. Acts upstream of or within autophagosome assembly. Located in extracellular space and lysosome. Is expressed in several structures, including central nervous system; extraembryonic component; eye; genitourinary system; and optic nerve. Used to study neuronal ceroid lipofuscinosis 10. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Orthologous to human CTSD (Cathepsin D). [provided by Alliance of Genome Resources, Apr 2022]

Ctsd Products(1)

mRNA	Protein	Name
NM_009983.3	NP_034113.1	cathepsin D precursor

Ctsd Protein Structure

A1_Propeptide

Cathepsin_D2

0
100
200
300
410 a.a.

Protein Preferred Names

Protein Names

cathepsin D

Recombinant Ctsd Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7749	Cathepsin D Protein, Mouse (HEK293, His)	P18242 (I21-L410)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-137978A	Ezurpimtrostat hydrochloride	Inhibitor	98.29%	Phase 2
HY-137978	Ezurpimtrostat	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS03328	CTSD Human Pre-designed siRNA Set A	/	Unkown
HY-RS03329	Ctsd Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS03330	Ctsd Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ctsd	NCBI	NCBI:1509

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