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Ddit3 - DNA-damage inducible transcript 3 Gene

Also Known as chop; CHOP10; CHOP-10; gadd153; AltDDIT3

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13198

Summary

Enables several functions, including cAMP response element binding protein binding activity; protein heterodimerization activity; and transcription regulator inhibitor activity. Involved in several processes, including blood vessel maturation; intrinsic apoptotic signaling pathway; and regulation of transcription, DNA-templated. Acts upstream of or within ER overload response; negative regulation of fat cell differentiation; and sensory perception of sound. Located in late endosome and nucleus. Part of CHOP-C/EBP complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3). [provided by Alliance of Genome Resources, Apr 2022]

Ddit3 Products (2)

mRNA	Protein	Name
NM_001290183.1	NP_001277112.1	DNA damage-inducible transcript 3 protein
NM_007837.4	NP_031863.3	DNA damage-inducible transcript 3 protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15601821	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	23624402	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	15601821	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	1547942	MGI
enables cAMP response element binding protein binding	IDA IDA: Inferred from direct assay	23624402	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10713066	MGI
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	23624402	MGI
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	1547942	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	15601821	MGI
enables transcription regulator activator activity	IDA IDA: Inferred from direct assay	10523647	MGI
enables transcription regulator inhibitor activity	IDA IDA: Inferred from direct assay	1547942	MGI
enables transcription regulator inhibitor activity	IGI IGI: Inferred from genetic interaction	1547942	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within ER overload response	IMP IMP: Inferred from mutant phenotype	11854325	MGI
involved in anterior/posterior axis specification	IDA IDA: Inferred from direct assay	16434966	MGI
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	22265908	MGI
involved in artery development	IMP IMP: Inferred from mutant phenotype	24530784	MGI
involved in blood vessel maturation	IMP IMP: Inferred from mutant phenotype	22265908	MGI
involved in endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	23624402	MGI
acts upstream of or within endoplasmic reticulum unfolded protein response	IMP IMP: Inferred from mutant phenotype	15601821	MGI
involved in establishment of protein localization to mitochondrion	IDA IDA: Inferred from direct assay	14752510	MGI
involved in gene expression	IGI IGI: Inferred from genetic interaction	24530784	MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	23624402	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	11854325	MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	9531536	MGI
involved in intrinsic apoptotic signaling pathway in response to nitrosative stress	IDA IDA: Inferred from direct assay	14752510	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	22242125	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19752026	MGI
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	16434966	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	26370079	MGI
involved in negative regulation of determination of dorsal identity	IDA IDA: Inferred from direct assay	16434966	MGI
acts upstream of or within negative regulation of fat cell differentiation	IGI IGI: Inferred from genetic interaction	22441668	MGI
involved in negative regulation of myoblast differentiation	IMP IMP: Inferred from mutant phenotype	22242125	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16434966	MGI
involved in negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	1547942	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	21159964	MGI
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	16135078	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	10523647	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15601821	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15601821	MGI
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15775988	MGI
involved in release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	19752026	MGI
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	19752026	MGI
involved in response to platelet-derived growth factor	IMP IMP: Inferred from mutant phenotype	24530784	MGI
involved in response to starvation	IDA IDA: Inferred from direct assay	22242125	MGI
involved in response to wounding	IMP IMP: Inferred from mutant phenotype	24530784	MGI
acts upstream of or within sensory perception of sound	IGI IGI: Inferred from genetic interaction	30188326	MGI
involved in vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	24530784	MGI
involved in vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	24530784	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of CHOP-C/EBP complex	IPI IPI: Inferred from physical interaction	1547942	MGI
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	10523647	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	1547942	MGI
located in late endosome	IDA IDA: Inferred from direct assay	23028046	MGI
located in nucleus	IDA IDA: Inferred from direct assay	1547942	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
DNA damage-inducible transcript 3 protein	C/EBP homoologous protein 10 C/EBP zeta CCAAT/enhancer-binding protein homologous protein DDIT-3 alternative DDIT3 proteins c/EBP-homologous protein 10 growth arrest and DNA-damage-inducible protein GADD153

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03614	DDIT3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-183004	NCP26		/	Unkown
HY-RS18059	Ddit3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24534	Ddit3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ddit3	NCBI	NCBI:1649