Twist2 - twist basic helix-loop-helix transcription factor 2 Gene

Also Known as Dermo1; bHLHa39

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13345

Summary

Enables DNA-binding transcription factor activity; chromatin binding activity; and protein domain specific binding activity. Involved in negative regulation of transcription, DNA-templated. Acts upstream of or within several processes, including face morphogenesis; negative regulation of cell differentiation; and negative regulation of macromolecule metabolic process. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; embryo mesenchyme; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in Barber-Say syndrome; ablepharon macrostomia syndrome; and focal dermal hypoplasia. Orthologous to human TWIST2 (twist family bHLH transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Twist2 Products (1)

mRNA Protein Name
NM_007855.3 NP_031881.1 twist-related protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
7589808 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
16831897 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14654692 MGI
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
15030764 MGI
enables transcription factor binding IDA
IDA: Inferred from direct assay
14654692 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19090621 MGI
acts upstream of or within cornea development in camera-type eye IMP
IMP: Inferred from mutant phenotype
20574024 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IGI
IGI: Inferred from genetic interaction
15030764 MGI
acts upstream of or within face morphogenesis IMP
IMP: Inferred from mutant phenotype
20574024 MGI
acts upstream of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
20574024 MGI
acts upstream of macrophage cytokine production IGI
IGI: Inferred from genetic interaction
16831897 MGI
acts upstream of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
16831897 MGI
acts upstream of myeloid cell differentiation IMP
IMP: Inferred from mutant phenotype
19090621 MGI
acts upstream of or within negative regulation of DNA binding IDA
IDA: Inferred from direct assay
14654692 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
7589808 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19090621 MGI
acts upstream of or within negative regulation of macrophage cytokine production IGI
IGI: Inferred from genetic interaction
16831897 MGI
acts upstream of or within negative regulation of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
16831897 MGI
acts upstream of or within negative regulation of molecular function IDA
IDA: Inferred from direct assay
15030764 MGI
acts upstream of or within negative regulation of myeloid cell differentiation IMP
IMP: Inferred from mutant phenotype
19090621 MGI
acts upstream of or within negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
15030764 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16831897 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
14654692 MGI
acts upstream of or within negative regulation of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
16831897 MGI
acts upstream of or within negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
16831897 MGI
acts upstream of or within osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
15030764 MGI
acts upstream of or within positive regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
20574024 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7589808 MGI
acts upstream of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
16831897 MGI
acts upstream of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
16831897 MGI
Cellular Component GO Annotation Evidence References Source
part of transcription regulator complex IPI
IPI: Inferred from physical interaction
7589808 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

twist-related protein 2

  • dermis-expressed protein 1

  • twist homolog 2

Twist2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Twist2 Q9D030 Runx2 Mus musculus Q08775
Anti Bait CoIP
20655471
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15282 TWIST2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21968 Twist2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28485 Twist2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Twist2 NCBI NCBI:117581