Dkk1 - dickkopf WNT signaling pathway inhibitor 1 Gene

Also Known as mdkk-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13380

Summary

Predicted to enable co-receptor binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Involved in several processes, including modulation of age-related behavioral decline; negative regulation of cellular component organization; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including Wnt signaling pathway involved in somitogenesis; embryonic morphogenesis; and negative regulation of signal transduction. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; embryo mesenchyme; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf Wnt signaling pathway inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]

Dkk1 Products (1)

mRNA Protein Name
NM_010051.3 NP_034181.2 dickkopf-related protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16126904 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of Wnt signaling pathway IDA
IDA: Inferred from direct assay
18462699 MGI
acts upstream of or within Wnt signaling pathway involved in somitogenesis IGI
IGI: Inferred from genetic interaction
18257070 MGI
acts upstream of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
18257070 MGI
acts upstream of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
18403408 MGI
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
18403408 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: Inferred from genetic interaction
15242796 MGI
acts upstream of or within endoderm development IMP
IMP: Inferred from mutant phenotype
18403408 MGI
acts upstream of or within endoderm formation IDA
IDA: Inferred from direct assay
18462699 MGI
acts upstream of or within face morphogenesis IMP
IMP: Inferred from mutant phenotype
17699607 MGI
acts upstream of or within forebrain development IGI
IGI: Inferred from genetic interaction
17127040 MGI
acts upstream of or within hair follicle development IDA
IDA: Inferred from direct assay
16682203 MGI
acts upstream of or within head morphogenesis IGI
IGI: Inferred from genetic interaction
18403408 MGI
involved in heart induction IDA
IDA: Inferred from direct assay
18297060 MGI
involved in learning or memory IDA
IDA: Inferred from direct assay
23164821 MGI
involved in limb development IMP
IMP: Inferred from mutant phenotype
18505822 MGI
acts upstream of or within mesoderm formation IDA
IDA: Inferred from direct assay
18462699 MGI
involved in motor learning IDA
IDA: Inferred from direct assay
25318560 MGI
acts upstream of or within negative regulation of BMP signaling pathway IDA
IDA: Inferred from direct assay
19850029 MGI
acts upstream of or within negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
16126904 MGI
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
26206087 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
17128274 MGI
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
17027228 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
15143170 MGI
involved in negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
16805831 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
18403408 MGI
involved in negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
29643768 MGI
involved in negative regulation of ossification IMP
IMP: Inferred from mutant phenotype
18505822 MGI
involved in negative regulation of presynapse assembly IDA
IDA: Inferred from direct assay
29643768 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17128274 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19850024 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
23164821 MGI
involved in positive regulation of midbrain dopaminergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
21347250 MGI
acts upstream of or within regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
17127040 MGI
involved in regulation of synapse organization IDA
IDA: Inferred from direct assay
25318560 MGI
involved in regulation of synaptic transmission, glutamatergic IDA
IDA: Inferred from direct assay
25318560 MGI
acts upstream of or within response to retinoic acid IDA
IDA: Inferred from direct assay
17064353 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dickkopf-related protein 1

  • dickkopf homolog 1

  • dickkopf-1

  • dickkopf-like protein 1

  • dkk-1

Recombinant Dkk1 Proteins

Cat. No. Product Name Accession Purity
HY-P7154 DKK-1 Protein, Mouse (CHO) O54908 (S30-H272) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72969 DKK-1 Protein, Mouse (HEK293, His) O54908 (T32-H272) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14930A Mirodenafil dihydrochloride 99.11% Unkown
HY-14930 Mirodenafil 99.88% Unkown

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99906 Sirexatamab 99.84% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-11035 WAY-262611 99.96% Unkown
HY-D0961 Gallocyanine chloride Activator 92.00% Unkown
HY-N5124 Meloside A Inhibitor 98.72% Unkown
HY-N2276 Nodakenetin Activator 99.66% Unkown
HY-RS03787 DKK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-14930S Mirodenafil-d7 / Unkown
HY-162970 XD23 Activator / Unkown
HY-175219 CA-II/Dkk1-IN-1 Inhibitor / Unkown
HY-W185542 E09241 / Unkown
HY-RS16543 Dkk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22975 Dkk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992113 Evabosmig Activator / Unkown
HY-P991569 PF-04840082 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dkk1 NCBI NCBI:22943