COX6C - cytochrome c oxidase subunit 6C Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1345

About COX6C

Cytogenetic location: 8q22.2 Genomic coordinates (GRCh38): 8:99,877,865-99,893,707 (from NCBI)

This gene has 11 transcripts (splice variants), 82 orthologues and is associated with 36 phenotypes. Ubiquitous expression in heart (RPKM 104.1), colon (RPKM 92.2) and 25 other tissues.

Summary

Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate Cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]

COX6C Products (1)

mRNA Protein Name
NM_004374.4 NP_004365.1 cytochrome c oxidase subunit 6C

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17500595 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
30030519 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COX6C Protein Structure

COX6C

COX6C: Cytochrome c oxidase subunit VIc (3 - 75)

  • 0
  • 75 a.a.
Protein Preferred Names Protein Names

cytochrome c oxidase subunit 6C

  • cytochrome c oxidase polypeptide VIc

COX6C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
COX6C P09669 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
COX6C P09669 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
COX6C P09669 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
COX6C P09669 SAT1 Homo sapiens P21673
Validated Y2H
32296183
Intra
COX6C P09669 SAT1 Homo sapiens P21673
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

COX6C Antibodies

Cat. No. Product Name Application Reactivity
HY-P82866 Cytochrome C Oxidase subunit Vic Antibody (YA2611) WB, IHC-P Human, Mouse, Rat
HY-P82866A Cytochrome C Oxidase subunit Vic Antibody (YA2611)(PBS only) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Leiomyoma

  • Leiomyomatous Neoplasm

  • Leiomyomatous Tumor

  • Leiomyomas

  • Fibroid Tumor

  • Uterine Fibroids
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Mitochondrial Complex Iv Deficiency, Nuclear Type 1

  • Cytochrome C Oxidase Deficiency

  • Mitochondrial Complex Iv Deficiency

  • Cox Deficiency

  • Cytochrome-C Oxidase Deficiency Disease

  • MC1DN4

  • Cytochrome-C Oxidase Deficiency

  • MC4DN1

  • Mitochondrial Complex I Deficiency, Nuclear Type 4

  • Complex 4 Mitochondrial Respiratory Chain Deficiency

  • Complex Iv Deficiency

  • Mitochondrial Complex 1 Deficiency, Nuclear Type 4

  • Nuclear Type Mitochondrial Complex I Deficiency 4

  • Deficiency Of Mitochondrial Respiratory Chain Complex4

  • MT-C4D

  • Complex Iv Mitochondrial Respiratory Chain Deficiency

  • Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency

  • Mitochondrial Complex Iv Deficiency, Nuclear, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03072 COX6C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21536 Cox6c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28054 Cox6c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus COX6C MGD MGI:104614
Rattus norvegicus COX6C RGD RGD:620616
Others COX6C NCBI