Drd4 - dopamine receptor D4 Gene

Also Known as D4R; Drd-4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13491

About Drd4

Chromosome 7: 140,871,919-140,876,377 forward strand.GRCm39:CM001000.3

This gene has 2 transcripts (splice variants), 247 orthologues, 32 paralogues and is associated with 11 phenotypes. Biased expression in ovary adult (RPKM 6.8), testis adult (RPKM 3.5) and 4 other tissues.

Summary

Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in regulation of circadian rhythm and regulation of postsynaptic neurotransmitter receptor internalization. Acts upstream of or within several processes, including adenylate cyclase-inhibiting Dopamine Receptor signaling pathway; behavioral response to cocaine; and inhibitory postsynaptic potential. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system gland; integumental system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and dyslexia. Orthologous to human DRD4 (Dopamine Receptor D4). [provided by Alliance of Genome Resources, Apr 2022]

Drd4 Products (3)

mRNA Protein Name
NM_001412325.1 NP_001399254.1 D(4) dopamine receptor isoform 2
NM_007878.4 NP_031904.1 D(4) dopamine receptor isoform 1
NM_001412326.1 NP_001399255.1 D(4) dopamine receptor isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IMP
IMP: Inferred from mutant phenotype
11356863 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adenylate cyclase-inhibiting dopamine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
14684868 MGI
acts upstream of or within adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
9323127 MGI
acts upstream of or within behavioral response to cocaine IMP
IMP: Inferred from mutant phenotype
9323127 MGI
acts upstream of or within fear response IMP
IMP: Inferred from mutant phenotype
11860516 MGI
acts upstream of or within inhibitory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
11356863 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
24048828 MGI
acts upstream of or within regulation of dopamine metabolic process IMP
IMP: Inferred from mutant phenotype
9323127 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization EXP
EXP: Inferred from Experiment
18832154 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
18832154 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
18832154 MGI
acts upstream of or within response to amphetamine IMP
IMP: Inferred from mutant phenotype
9323127 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
18832154 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
18832154 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
18832154 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Drd4 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (41 - 378)

7tm_GPCRs

7tm_GPCRs: cd14964 (66 - 88)

7tm_GPCRs

7tm_GPCRs: cd14964 (105 - 127)

7tm_GPCRs

7tm_GPCRs: cd14964 (148 - 164)

7tm_GPCRs

7tm_GPCRs: cd14964 (184 - 207)

7tm_GPCRs

7tm_GPCRs: cd14964 (312 - 334)

7tm_GPCRs

7tm_GPCRs: cd14964 (346 - 371)

  • 0
  • 100
  • 200
  • 300
  • 387 a.a.
Protein Preferred Names Protein Names

D(4) dopamine receptor

  • d(2C) dopamine receptor

  • dopamine receptor 4

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-107121 Ondelopran Antagonist / Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125751 UCSF924 Agonist 99.53% Unkown
HY-147398 Dopamine D4 receptor antagonist-1 Antagonist 98.59% Unkown
HY-103407A PD 168568 dihydrochloride Antagonist 99.71% Unkown
HY-RS04004 Drd4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-103407 PD 168568 Antagonist / Unkown
HY-RS04003 DRD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04005 Drd4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Drd4 NCBI NCBI:1815