1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. UCSF924

UCSF924 

Cat. No.: HY-125751
Handling Instructions

UCSF924 is a potent and specific dopamine D4 receptor (DRD4) partial agonist with a EC50 of 4.2 nM. UCSF924 has a high-affinity with a Ki value of 3 nM for DRD4 and shows no measurable affinity for D2, D3 or the F261V/L328F D4 mutant. UCSF924 is a 7.4-fold bias toward arrestin over Gαi/o signaling, referenced to quinpirole.

For research use only. We do not sell to patients.

UCSF924 Chemical Structure

UCSF924 Chemical Structure

CAS No. : 1434515-70-4

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Description

UCSF924 is a potent and specific dopamine D4 receptor (DRD4) partial agonist with a EC50 of 4.2 nM. UCSF924 has a high-affinity with a Ki value of 3 nM for DRD4 and shows no measurable affinity for D2, D3 or the F261V/L328F D4 mutant. UCSF924 is a 7.4-fold bias toward arrestin over Gαi/o signaling, referenced to quinpirole[1].

IC50 & Target

Ki: 3 nM (dopamine D4 receptor)[1]

Molecular Weight

322.40

Formula

C₂₀H₂₂N₂O₂

CAS No.

1434515-70-4

SMILES

OC1=CC(CNCCCOC2=CC=CC=C2)=NC3=CC=C(C)C=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

UCSF924UCSF 924UCSF-924Dopamine ReceptorprobeInhibitorinhibitorinhibit

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