TRIM40 - tripartite motif containing 40 Gene

Also Known as RNF35

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 135644

About TRIM40

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,136,140-30,148,735 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 76 orthologues and 80 paralogues. Biased expression in small intestine (RPKM 3.6), duodenum (RPKM 3.4) and 4 other tissues.

Summary

This gene encodes a member of the tripartite motif (TRIM) protein family. The encoded protein may play a role as a negative regulator against inflammation and carcinogenesis in the gastrointestinal tract. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Feb 2014]

TRIM40 Products (2)

mRNA Protein Name
NM_001286633.2 NP_001273562.1 E3 ubiquitin ligase TRIM40 isoform a
NM_138700.4 NP_619645.1 E3 ubiquitin ligase TRIM40 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21474709 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
21474709 GOA
involved in negative regulation of protein catabolic process IDA
IDA: Inferred from direct assay
21474709 GOA
involved in negative regulation of protein localization to nucleus IDA
IDA: Inferred from direct assay
21474709 GOA
involved in protein neddylation IDA
IDA: Inferred from direct assay
21474709 GOA
Cellular Component GO Annotation Evidence References Source
part of IkappaB kinase complex IDA
IDA: Inferred from direct assay
21474709 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM40 Protein Structure

zf-C3HC4_2

zf-C3HC4_2: Zinc finger, C3HC4 type (RING finger) (14 - 56)

  • 0
  • 100
  • 200
  • 258 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin ligase TRIM40

  • RING finger protein 35

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15045 TRIM40 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TRIM40 RGD RGD:1359645
Bos taurus TRIM40 VGNC VGNC:54243
Mus musculus TRIM40 MGD MGI:2684881
Others TRIM40 NCBI